{"id":"W2077507971","doi":"10.1016/j.bone.2013.10.020","title":"Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity","year":2013,"lang":"en","type":"article","venue":"Bone","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Sclerostin; Wnt signaling pathway; Chemistry; Internal medicine; Endocrinology; Osteoblast; Sirtuin 1; Klotho; Signal transduction; Cell biology; Downregulation and upregulation; Biology; Medicine; Biochemistry; Gene; Kidney","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003434093,0.0003879962,0.0007466666,0.0003807343,0.0001695857,0.00006412892,0.0001725485,0.0002605067,0.001352814],"category_scores_gemma":[0.0004878979,0.0003175026,0.0001132731,0.0005969895,0.0001192344,0.0003375165,0.0001646942,0.0005649443,0.0004793917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298315,"about_ca_system_score_gemma":0.0001244239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068268,"about_ca_topic_score_gemma":0.0009932602,"domain_scores_codex":[0.9972607,0.0001381539,0.0005604837,0.0006172941,0.0006487027,0.0007746087],"domain_scores_gemma":[0.9983999,0.0001338395,0.0001275917,0.000459162,0.0002587325,0.0006207683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000326423,0.0004496794,0.009376472,0.00008160301,0.0000103953,0.0002061919,0.0003668555,0.00002520942,0.9633524,0.00001060998,0.005096689,0.02069748],"study_design_scores_gemma":[0.007471233,0.001990657,0.3726069,0.001889211,0.00003587381,0.0001992231,0.0003146022,0.0001273232,0.6146246,0.00003970697,0.0002678327,0.0004328006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941154,0.0003220128,0.0001017454,0.002106002,0.0002949808,0.001284653,0.00001624608,0.0001090906,0.001649907],"genre_scores_gemma":[0.9941714,0.00001953059,0.0007333898,0.000681216,0.0005772162,0.0002016782,0.00004406938,0.00006610243,0.003505438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3632304,"threshold_uncertainty_score":0.9999277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02074238913007108,"score_gpt":0.2726293396355891,"score_spread":0.251886950505518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}