{"id":"W2077512653","doi":"10.1007/s13181-014-0431-2","title":"Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose","year":2014,"lang":"en","type":"article","venue":"Journal of Medical Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McGill University","keywords":"Acetaminophen; Medicine; Urine; Adduct; Urinary system; acetaminophen overdose; Internal medicine; Endocrinology; Pharmacology; Chemistry; Acetylcysteine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003282215,0.0003553763,0.0007667648,0.0002842126,0.0003001868,0.00002668708,0.0004381927,0.001203208,0.001558903],"category_scores_gemma":[0.001823857,0.0003292215,0.0001882395,0.000311663,0.0006990458,0.0005150476,0.0001355592,0.002123528,0.00001840915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788709,"about_ca_system_score_gemma":0.0003915145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001097049,"about_ca_topic_score_gemma":0.00002811891,"domain_scores_codex":[0.9948115,0.002008259,0.001341283,0.0004176466,0.0008514374,0.0005698865],"domain_scores_gemma":[0.9971778,0.00055946,0.001028227,0.0002387159,0.0003864749,0.0006092968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002912166,0.001541999,0.002235348,0.0003738387,0.0004618248,0.00034689,0.001284597,0.00009620281,0.9571577,0.001474079,0.005788689,0.02632669],"study_design_scores_gemma":[0.01458341,0.004739671,0.03843769,0.0004227016,0.0006657222,0.005885939,0.0003906024,0.003872762,0.8347774,0.002919559,0.09237724,0.0009273392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867027,0.001345892,0.0007921522,0.009054853,0.0009565656,0.0006980573,0.00005960984,0.00003708919,0.0003530944],"genre_scores_gemma":[0.9960045,0.0004206068,0.0009460605,0.001034138,0.001166906,0.00007227117,0.00002865647,0.00003282664,0.0002940453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1223803,"threshold_uncertainty_score":0.999916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06438524563735741,"score_gpt":0.382456095357699,"score_spread":0.3180708497203416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}