{"id":"W2077533783","doi":"10.1016/j.cellsig.2008.12.006","title":"SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux","year":2008,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canada Research Chairs; National Cancer Institute; Ontario Genomics Institute; Genome Canada","keywords":"Syk; Cell biology; Phosphorylation; CD22; Tyrosine phosphorylation; B cell; Biology; Regulator; Immune system; Signal transduction; B-cell receptor; Chemistry; Tyrosine kinase; Biochemistry; Immunology; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708368,0.0004613125,0.0003038372,0.0003406673,0.0004825113,0.001022581,0.0003113081,0.0003385846,0.002916991],"category_scores_gemma":[0.0002976143,0.0002059085,0.000283345,0.0002655863,0.0003602265,0.0004666985,0.0005854186,0.0008026804,0.001102123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007333628,"about_ca_system_score_gemma":0.0002362669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006660358,"about_ca_topic_score_gemma":0.0008772643,"domain_scores_codex":[0.9997103,0.00003938265,0.000007932721,0.00003301193,0.00006457538,0.0001447705],"domain_scores_gemma":[0.9998117,0.0000300674,0.00002369015,0.00001694354,0.00002897273,0.00008863966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000487974,0.00004064215,0.0009775414,0.00006143187,0.00001250191,0.0002155975,0.00002993202,0.0001257638,0.991947,0.0007793264,0.0005454363,0.004776695],"study_design_scores_gemma":[0.0001010299,0.0002593796,0.04005367,0.0000246912,0.00003684877,0.001073161,0.0002445511,0.0046407,0.9392272,0.001883006,0.01243248,0.00002329335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821522,0.004093342,0.003048427,0.0003921253,0.00008593951,0.00001794769,0.0002454944,0.0001326763,0.009831814],"genre_scores_gemma":[0.9918283,0.001083669,0.001135785,0.0001262037,0.0000482867,0.00002099815,0.0004093902,0.00004028549,0.005307104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002916991,"threshold_uncertainty_score":0.009758294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749735185797637,"score_gpt":0.2070412855785023,"score_spread":0.189543933720526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}