{"id":"W2077548349","doi":"10.1016/j.expneurol.2013.08.007","title":"The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain","year":2013,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Striatum; Neurotoxicity; Excitotoxicity; Neuroprotection; Kynurenine pathway; Indoleamine 2,3-dioxygenase; Quinolinic acid; NMDA receptor; Pharmacology; Kynurenine; Chemistry; Neuroscience; Biology; Dopamine; Internal medicine; Receptor; Medicine; Biochemistry; Toxicity; Tryptophan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454525,0.0007293838,0.0004287102,0.0007316087,0.0002974592,0.0005486552,0.0004180801,0.0006314935,0.001862646],"category_scores_gemma":[0.0001564896,0.0003504952,0.0004125619,0.0003072866,0.000719996,0.0005079572,0.0002280637,0.001237382,0.0004987156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004662186,"about_ca_system_score_gemma":0.0004744489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462067,"about_ca_topic_score_gemma":0.002636458,"domain_scores_codex":[0.9997287,0.0000277738,0.00002970796,0.00006196744,0.0000491127,0.0001027798],"domain_scores_gemma":[0.9996564,0.00003148919,0.0001174423,0.00005139218,0.00003102277,0.00011214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003393622,0.00006476521,0.00009796851,0.00002462997,0.000007820805,0.00004293222,0.00001989069,0.00002701284,0.9987127,0.0001997561,0.00004011604,0.0004231526],"study_design_scores_gemma":[0.00003645791,0.0003539707,0.001741799,0.00001026784,0.00003408082,0.0001259975,0.00003894487,0.0003400266,0.9962674,0.0001377241,0.0009076594,0.000005760173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931625,0.001467615,0.002996468,0.0002756922,0.00008965212,0.00003038884,0.0005952286,0.0001851463,0.001197277],"genre_scores_gemma":[0.9870397,0.001242974,0.002358436,0.0001032107,0.00003302929,0.00007290881,0.0008775061,0.00007629753,0.008195951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001862646,"threshold_uncertainty_score":0.006231189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141380120296621,"score_gpt":0.2480673461831523,"score_spread":0.2339293341534902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}