{"id":"W2077585283","doi":"10.1021/bi0617613","title":"The GCN4 bZIP Targets Noncognate Gene Regulatory Sequences:  Quantitative Investigation of Binding at Full and Half Sites","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Hospital for Sick Children","keywords":"Leucine zipper; Binding site; bZIP domain; Chemistry; Electrophoretic mobility shift assay; Plasma protein binding; Dissociation constant; Zipper; Affinities; DNA; Cooperative binding; Stereochemistry; Biophysics; Biochemistry; Molecular biology; Transcription factor; Biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000422116,0.0005782312,0.0004833471,0.0003346641,0.000268424,0.0002911351,0.0007351849,0.0004834687,0.001671369],"category_scores_gemma":[0.0004440005,0.0002542453,0.0001968882,0.0003101279,0.000388278,0.0003050202,0.0003433372,0.0007811558,0.0006016395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658856,"about_ca_system_score_gemma":0.0001727322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128751,"about_ca_topic_score_gemma":0.001462955,"domain_scores_codex":[0.9994618,0.00007825996,0.00002678832,0.0001717386,0.0001946729,0.00006665766],"domain_scores_gemma":[0.9995821,0.0001119519,0.00007455365,0.000047098,0.00009711212,0.00008715581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003779242,0.000009184862,0.0001081866,0.00001739639,0.000002642404,0.000004695931,0.000007583017,0.00001840501,0.9994528,0.00001438548,0.000005432258,0.0003215485],"study_design_scores_gemma":[0.000002566169,0.00004028857,0.002263349,0.000002049396,0.000004871666,0.00007972695,0.00001519287,0.0007729757,0.9961985,0.00001801756,0.0005989841,0.000003356194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728915,0.001746941,0.02357629,0.00006664397,0.00001922369,0.00004856306,0.0003883963,0.0001145007,0.001147952],"genre_scores_gemma":[0.9639613,0.0009549352,0.02869914,0.0001211752,0.00001064427,0.0001579031,0.001731374,0.00008031937,0.004283189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671369,"threshold_uncertainty_score":0.005591273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177015884556382,"score_gpt":0.2511508316278069,"score_spread":0.2334492431721687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}