{"id":"W2077585283","doi":"10.1021/bi0617613","title":"The GCN4 bZIP Targets Noncognate Gene Regulatory Sequences:  Quantitative Investigation of Binding at Full and Half Sites","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Hospital for Sick Children","keywords":"Leucine zipper; Binding site; bZIP domain; Chemistry; Electrophoretic mobility shift assay; Plasma protein binding; Dissociation constant; Zipper; Affinities; DNA; Cooperative binding; Stereochemistry; Biophysics; Biochemistry; Molecular biology; Transcription factor; Biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006532111,0.0001522854,0.0001215166,0.00002076963,0.0001972239,0.00001772602,0.0001619185,0.0001955362,0.000007743159],"category_scores_gemma":[0.0001752862,0.0001218307,0.00005793431,0.00007248283,0.0003036099,0.00000433999,0.0001080219,0.00005415149,0.000003458219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002453464,"about_ca_system_score_gemma":0.00005397985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007442626,"about_ca_topic_score_gemma":0.00001400653,"domain_scores_codex":[0.9990209,0.00003918137,0.0002527915,0.0003053599,0.0001579823,0.000223735],"domain_scores_gemma":[0.9992542,0.00006869354,0.0002064004,0.0002832704,0.00009304257,0.00009442493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101204,0.000005720199,0.0008422534,0.00003640665,0.0000354704,0.000002446604,0.00006579122,9.423236e-7,0.9979873,0.0001095154,0.0001475817,0.0006564916],"study_design_scores_gemma":[0.0001591556,0.00009879802,0.0005174146,0.00003298105,0.00001455257,0.00001923743,0.000209334,0.00001037954,0.9980414,0.0003110624,0.0004307032,0.0001550151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993508,0.005216875,0.0005822765,0.00008173878,0.00005736775,0.0001187271,0.00002063346,0.000009589988,0.0004047861],"genre_scores_gemma":[0.9946856,0.0002958549,0.004128528,0.00004157384,0.00009653728,0.00001021939,0.00008897479,0.00001643255,0.0006363004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00492102,"threshold_uncertainty_score":0.4968111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177015884556382,"score_gpt":0.2511508316278069,"score_spread":0.2334492431721687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}