{"id":"W2077599560","doi":"10.1074/jbc.c110.150482","title":"Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Academy of Finland; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Zinc finger; Transcription factor; Biology; Structural motif; Genetics; DNA; DNA-binding domain; Sequence motif; DNA-binding protein; Eukaryotic transcription; LIM domain; Transcription (linguistics); Computational biology; Cell biology; Gene; Promoter; Biochemistry; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233309,0.0001653468,0.000152716,0.00016145,0.0001527089,0.000209018,0.0001935766,0.0002462669,0.0004142053],"category_scores_gemma":[0.0001992059,0.00009592873,0.0001733989,0.0001312902,0.0002022522,0.0002146064,0.0001101087,0.0004530915,0.0002187496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236227,"about_ca_system_score_gemma":0.000247293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006012282,"about_ca_topic_score_gemma":0.0007617921,"domain_scores_codex":[0.9999418,0.000009072671,0.000003623564,0.00001361167,0.00001981098,0.00001207181],"domain_scores_gemma":[0.9999138,0.00001686843,0.00002554459,0.000006762886,0.00001108662,0.00002591209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001355521,0.0000445422,0.0008839308,0.00003326018,0.000005540425,0.0001091091,0.0000269114,0.000347774,0.995002,0.0002512379,0.00005310148,0.00310699],"study_design_scores_gemma":[0.0000861943,0.0004754328,0.06960151,0.00002720996,0.00005555958,0.002892373,0.0001826551,0.006199684,0.9092966,0.001164548,0.009990173,0.00002794399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952884,0.000822378,0.003124266,0.00007018579,0.000006645745,0.00001395492,0.0002241448,0.00002088871,0.0004293124],"genre_scores_gemma":[0.993149,0.0004233069,0.005164143,0.00003868297,0.000005941126,0.00001315479,0.0007101807,0.000006421745,0.0004892153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006012282,"threshold_uncertainty_score":0.001622498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466424083120217,"score_gpt":0.223840284271881,"score_spread":0.1991760434406788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}