{"id":"W2077623699","doi":"10.1371/journal.pone.0019143","title":"Globular Adiponectin, Acting via AdipoR1/APPL1, Protects H9c2 Cells from Hypoxia/Reoxygenation-Induced Apoptosis","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta; York University","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Adiponectin; Apoptosis; Cell biology; Annexin; Mitochondrial ROS; Gene knockdown; TUNEL assay; Adiponectin receptor 1; Reactive oxygen species; Caspase 3; Caspase; Biology; Chemistry; Programmed cell death; Endocrinology; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426107,0.0004640925,0.0004077608,0.0001850104,0.0001916337,0.00021841,0.0002364016,0.000277114,0.001011809],"category_scores_gemma":[0.00009654173,0.0001576754,0.0003372583,0.0001806398,0.0001964964,0.0001514276,0.0001467325,0.0006842786,0.0003019894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002121838,"about_ca_system_score_gemma":0.0002612244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009596677,"about_ca_topic_score_gemma":0.001488195,"domain_scores_codex":[0.9998617,0.00002408196,0.00002321295,0.0000256676,0.00003302461,0.00003230917],"domain_scores_gemma":[0.9999117,0.00001522453,0.00002342114,0.00001560376,0.00001496145,0.00001917446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002757862,0.00005304662,0.0002491247,0.00008241032,0.0000135404,0.00007729833,0.00001521563,0.0001005641,0.9979766,0.00005346589,0.0001240905,0.0009788288],"study_design_scores_gemma":[0.0001025981,0.000938825,0.01090521,0.00001446779,0.00005598393,0.000229514,0.00005893046,0.001396002,0.9829369,0.00003895983,0.003312402,0.00001018446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914375,0.00294576,0.003299033,0.0002704182,0.0001186178,0.00005564966,0.0006862546,0.00009331793,0.00109333],"genre_scores_gemma":[0.9886035,0.002507168,0.003283256,0.0002601634,0.00004663569,0.0000834586,0.001735664,0.00002012315,0.003459997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011809,"threshold_uncertainty_score":0.003384888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05756416984586418,"score_gpt":0.2325158093474274,"score_spread":0.1749516395015632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}