{"id":"W2077628965","doi":"10.1021/bi061389r","title":"Tryptophan Solvent Exposure in Folded and Unfolded States of an SH3 Domain by <sup>19</sup>F and <sup>1</sup>H NMR","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Chemistry; Indole test; Solvent; Conformational isomerism; Solvent exposure; Tryptophan; Crystallography; Paramagnetism; Relaxation (psychology); Nuclear Overhauser effect; Proton; Nuclear magnetic resonance spectroscopy; Nuclear magnetic resonance; Stereochemistry; Molecule; Amino acid; Organic chemistry; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988594,0.0001515603,0.0001043952,0.0001347232,0.0001924098,0.0001963075,0.0001650294,0.0002139018,0.0004822534],"category_scores_gemma":[0.0002857157,0.0001093078,0.0001146604,0.0001403195,0.0002815534,0.00019042,0.000169434,0.0003207527,0.00008049794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002121206,"about_ca_system_score_gemma":0.00010156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036211,"about_ca_topic_score_gemma":0.001019733,"domain_scores_codex":[0.9999198,0.00001706834,0.000003853789,0.00001873286,0.00002012587,0.00002046553],"domain_scores_gemma":[0.9998479,0.00004900102,0.00005037739,0.00001041962,0.00002197078,0.00002032244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002392812,0.00000744036,0.000570209,0.00001734827,0.000005140896,0.00005041128,0.00005261863,0.00008631994,0.9978952,0.00003239499,0.00002505954,0.001018625],"study_design_scores_gemma":[0.00001850953,0.0001784665,0.02515809,0.000007862245,0.00001881222,0.0002413263,0.0001103525,0.002741312,0.9703992,0.0001115557,0.001001252,0.00001327752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979488,0.0002724699,0.00126818,0.00002809345,0.000003008269,0.000005718995,0.0001241633,0.00002278364,0.0003267966],"genre_scores_gemma":[0.9969153,0.0002348709,0.002127367,0.00003146791,0.00000691299,0.00001402115,0.0002771158,0.00001830598,0.000374625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036211,"threshold_uncertainty_score":0.002060413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002677371070186322,"score_gpt":0.2043169941934752,"score_spread":0.2016396231232889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}