{"id":"W2077697209","doi":"10.1210/endo.142.2.7982","title":"Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells<sup>1</sup>","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internal medicine; Endocrinology; Estrogen receptor; Estrogen; GNRHR; Biology; Autocrine signalling; Gonadotropin-releasing hormone; Messenger RNA; Receptor; Estrogen receptor alpha; Hormone; Luteinizing hormone; Gene; Medicine; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008730498,0.0002799502,0.0003363247,0.00007533546,0.0001893656,0.0000207688,0.0001347348,0.0002917938,0.000004843674],"category_scores_gemma":[0.00004482271,0.000218237,0.0000458879,0.0001010595,0.0003208239,0.00001462017,0.0001893124,0.0002928576,9.237008e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001877185,"about_ca_system_score_gemma":0.00004028916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002741962,"about_ca_topic_score_gemma":0.000009035874,"domain_scores_codex":[0.9983668,0.0002901163,0.000286725,0.0005102367,0.00009418111,0.0004519631],"domain_scores_gemma":[0.9994203,0.00008344968,0.0001240059,0.0002213889,0.00004218969,0.0001086185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002660254,0.00005710824,0.004670297,0.00007072165,0.00007529213,0.00005375234,0.0002895895,0.00007317468,0.9930986,0.0001571799,0.0001135011,0.001074741],"study_design_scores_gemma":[0.002422546,0.0005337172,0.02185174,0.00008116206,0.00004536298,0.0002144402,0.00007257632,0.000146449,0.9739598,0.00007135004,0.0003605017,0.0002403556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647374,0.03438792,0.00001618991,0.0002420728,0.0001295831,0.0004119843,0.00001574286,0.00001681915,0.00004232001],"genre_scores_gemma":[0.9751711,0.0241068,0.00029491,0.00004896421,0.0002078802,0.00002244306,0.00002543075,0.0000338584,0.00008860025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01913882,"threshold_uncertainty_score":0.8899446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005156892085401688,"score_gpt":0.2200451367485642,"score_spread":0.2148882446631625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}