{"id":"W2077697209","doi":"10.1210/endo.142.2.7982","title":"Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells<sup>1</sup>","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internal medicine; Endocrinology; Estrogen receptor; Estrogen; GNRHR; Biology; Autocrine signalling; Gonadotropin-releasing hormone; Messenger RNA; Receptor; Estrogen receptor alpha; Hormone; Luteinizing hormone; Gene; Medicine; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008789522,0.000189716,0.0001682855,0.0001478134,0.00008580275,0.0002199582,0.00008523768,0.0000896448,0.000796309],"category_scores_gemma":[0.0001016911,0.0001129631,0.0002049059,0.0001261414,0.0001568145,0.00009666527,0.00009649719,0.0001771594,0.0002948278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117475,"about_ca_system_score_gemma":0.0001188238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005742131,"about_ca_topic_score_gemma":0.0009199454,"domain_scores_codex":[0.9999319,0.00001252595,0.00000706448,0.00001030306,0.00002246342,0.00001575881],"domain_scores_gemma":[0.9999394,0.00001892151,0.00001419498,0.000008908206,0.00001072471,0.000007846656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001572734,0.00001719973,0.001611106,0.00004549509,0.00000761188,0.0001167928,0.00002770124,0.0000363067,0.9952133,0.00005467607,0.00006457177,0.002647959],"study_design_scores_gemma":[0.00003469503,0.0006557133,0.0667701,0.00001066735,0.00003632583,0.0009935234,0.0001851599,0.0006653492,0.9233761,0.00007312911,0.007192055,0.000007186223],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992959,0.004078514,0.001176639,0.00008648962,0.00002543649,0.0000152566,0.0002725874,0.00002970125,0.001356363],"genre_scores_gemma":[0.992227,0.002655662,0.001778558,0.00009887506,0.00001948745,0.00002392263,0.000884037,0.00001718188,0.002295384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000796309,"threshold_uncertainty_score":0.00266397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005156892085401688,"score_gpt":0.2200451367485642,"score_spread":0.2148882446631625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}