{"id":"W2077697398","doi":"10.1006/mthe.2000.0077","title":"Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors","year":2000,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Stem cell; Vesicular stomatitis virus; Bone marrow; Haematopoiesis; CD38; Transduction (biophysics); CD34; Viral vector; Cord blood; Virology; Genetic enhancement; Immunology; Molecular biology; Cell biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574445,0.000238693,0.0002286276,0.00007910892,0.0001677237,0.00004125213,0.0001332619,0.0001407812,0.0001291071],"category_scores_gemma":[0.000003644474,0.0002198403,0.00009996085,0.0001582774,0.0001781678,0.00001103006,0.00001526772,0.0001232865,0.000002705268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001082693,"about_ca_system_score_gemma":0.00004627899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008974013,"about_ca_topic_score_gemma":0.0001579966,"domain_scores_codex":[0.9984381,0.0002165695,0.0002787426,0.0004803577,0.0002931339,0.0002930932],"domain_scores_gemma":[0.9993194,0.000004146551,0.00009993897,0.0004124532,0.00008700086,0.00007701219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001569591,0.0001307174,0.0004453275,0.00001336289,0.0001618424,0.00001229055,0.0001138784,0.0003944408,0.9818833,0.000007407394,0.00002269203,0.0152451],"study_design_scores_gemma":[0.001918725,0.005265552,0.0004574704,0.00001499494,0.00002745449,0.00001891703,0.00002432385,0.00009779327,0.9916867,0.00003166433,0.0002073852,0.0002490048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971175,0.001819791,0.0003274125,0.0000732113,0.00003829671,0.0004076075,0.000008614754,0.00002154203,0.0001860646],"genre_scores_gemma":[0.998138,0.0005592213,0.0004911806,0.0001332006,0.0001181524,0.00003141982,0.0001293812,0.00005959657,0.0003398398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0149961,"threshold_uncertainty_score":0.8964826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829102356791838,"score_gpt":0.2711504399804154,"score_spread":0.252859416412497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}