{"id":"W2077697398","doi":"10.1006/mthe.2000.0077","title":"Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors","year":2000,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Stem cell; Vesicular stomatitis virus; Bone marrow; Haematopoiesis; CD38; Transduction (biophysics); CD34; Viral vector; Cord blood; Virology; Genetic enhancement; Immunology; Molecular biology; Cell biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247717,0.000356415,0.0002639012,0.0002975744,0.0001703965,0.0003643338,0.0002575466,0.0002115969,0.00195798],"category_scores_gemma":[0.0000905045,0.0001154216,0.0002755635,0.0002244998,0.0001834761,0.0001212588,0.0002134998,0.0006070154,0.000773389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089074,"about_ca_system_score_gemma":0.0002729805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007731337,"about_ca_topic_score_gemma":0.001080203,"domain_scores_codex":[0.9998304,0.00001501867,0.00001839182,0.0000303092,0.00007618256,0.00002976134],"domain_scores_gemma":[0.9999213,0.000007676666,0.00001828792,0.00001818576,0.00001203691,0.00002251654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005217334,0.0000287241,0.0001996991,0.00003006166,0.000003655731,0.00004864254,0.00003345896,0.00003927516,0.9968998,0.0002058334,0.0001169882,0.002341707],"study_design_scores_gemma":[0.00001984291,0.0002110864,0.002717354,0.000006712069,0.00001630914,0.000453548,0.00001716887,0.0007274773,0.9880421,0.00003896381,0.007745591,0.000003912871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728548,0.001687117,0.01746027,0.00009669847,0.00006099818,0.0004561524,0.002337897,0.0004113984,0.004634639],"genre_scores_gemma":[0.9604732,0.001721749,0.01934812,0.00008659856,0.00002748481,0.000497607,0.005938741,0.00007384414,0.01183261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195798,"threshold_uncertainty_score":0.006550133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829102356791838,"score_gpt":0.2711504399804154,"score_spread":0.252859416412497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}