{"id":"W2077708241","doi":"10.1128/mcb.26.5.1917-1931.2006","title":"RBP1 Family Proteins Exhibit SUMOylation-Dependent Transcriptional Repression and Induce Cell Growth Inhibition Reminiscent of Senescence","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute","keywords":"Biology; SUMO protein; Psychological repression; Retinoblastoma protein; Transcription factor; Histone deacetylase; Serum response factor; Cell biology; Cancer research; Histone; Cell cycle; Genetics; Cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002234324,0.0001951238,0.0001885964,0.00006227844,0.00008717067,0.00001491447,0.00007411822,0.0002854355,0.000007589464],"category_scores_gemma":[0.00001766418,0.0001860014,0.00006950204,0.00006544484,0.0001728899,0.000005891469,0.00008808204,0.0001146707,0.000001354274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007428253,"about_ca_system_score_gemma":0.00004330579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245565,"about_ca_topic_score_gemma":0.000009091217,"domain_scores_codex":[0.998684,0.0001585402,0.0003058704,0.0005064929,0.0001206238,0.0002244172],"domain_scores_gemma":[0.9994842,0.000008028848,0.0001310227,0.0002114016,0.00009434497,0.00007104747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007688615,0.00009491017,0.003094099,0.00007372432,0.00001055367,0.00001073455,0.00003700228,0.000004674352,0.994297,0.001734264,0.00002334251,0.0005427859],"study_design_scores_gemma":[0.0007215696,0.0003232752,0.002469247,0.00003209614,0.00002037728,0.00002273895,0.00005309047,0.0000248665,0.9943385,0.001218016,0.0005650166,0.0002112234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748938,0.004440763,0.01869183,0.00008411137,0.00005700282,0.0003673084,0.00004657706,0.00001191701,0.001406699],"genre_scores_gemma":[0.9981791,0.00018351,0.0008228164,0.00009884918,0.00008326237,0.00003542399,0.0004539519,0.00001936131,0.0001236944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02328534,"threshold_uncertainty_score":0.7584917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0075757618899784,"score_gpt":0.2046524158056702,"score_spread":0.1970766539156918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}