{"id":"W2077711228","doi":"10.1038/icb.2015.17","title":"Naive CD8<sup>+</sup> T‐cell precursors display structured TCR repertoires and composite antigen‐driven selection dynamics","year":2015,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Directorate for Biological Sciences; Medical Research Council; Biotechnology and Biological Sciences Research Council; Anthony Nolan; Wellcome Trust","keywords":"Repertoire; Biology; T-cell receptor; CD8; Antigen; Immune system; T cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003032321,0.0006604823,0.0009356348,0.0003368806,0.000651396,0.00003618667,0.0004588598,0.001820249,0.0001656137],"category_scores_gemma":[0.00006714279,0.0005741859,0.0001330912,0.0002493904,0.002211996,0.000169649,0.0004691957,0.001152718,0.0002321163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150797,"about_ca_system_score_gemma":0.0001500732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000618375,"about_ca_topic_score_gemma":0.0001612215,"domain_scores_codex":[0.9960964,0.001016962,0.0006721149,0.001105538,0.00004343938,0.001065494],"domain_scores_gemma":[0.9985163,0.0003219495,0.0003633893,0.0005057863,0.0001922343,0.0001003993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001221328,0.0002413746,0.0369261,0.00003171146,0.0004384215,0.00001751038,0.001487097,0.00005749441,0.953172,0.001579962,0.0006487418,0.004178272],"study_design_scores_gemma":[0.01267031,0.005771243,0.009719327,0.00006028702,0.0004319382,0.002260262,0.004525206,0.001626865,0.8804021,0.003879523,0.0766893,0.001963573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685478,0.02673625,0.0001981248,0.0003792309,0.001233708,0.0004688435,0.00009768953,0.0002130955,0.002125301],"genre_scores_gemma":[0.9923542,0.002870761,0.0002823274,0.0002516444,0.00006699709,0.00004437732,0.0007790126,0.00005121597,0.003299485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07604056,"threshold_uncertainty_score":0.999671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006387020040411905,"score_gpt":0.2087188404559359,"score_spread":0.202331820415524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}