{"id":"W2077711228","doi":"10.1038/icb.2015.17","title":"Naive CD8<sup>+</sup> T‐cell precursors display structured TCR repertoires and composite antigen‐driven selection dynamics","year":2015,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Directorate for Biological Sciences; Medical Research Council; Biotechnology and Biological Sciences Research Council; Anthony Nolan; Wellcome Trust","keywords":"Repertoire; Biology; T-cell receptor; CD8; Antigen; Immune system; T cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008091515,0.0001085687,0.0001027408,0.0001303616,0.00008007815,0.0003519733,0.000118766,0.000109282,0.001040065],"category_scores_gemma":[0.0002054341,0.0000910766,0.00005214435,0.0001028787,0.000152712,0.0001687592,0.0001324052,0.0002217348,0.0004528767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008889915,"about_ca_system_score_gemma":0.00006357692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002356848,"about_ca_topic_score_gemma":0.0003376691,"domain_scores_codex":[0.9999413,0.000007938885,0.000005751131,0.00001894536,0.00001341168,0.00001253518],"domain_scores_gemma":[0.9998676,0.00002478256,0.00003764116,0.0000234712,0.00002322424,0.00002320968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009529057,0.000009773605,0.007024213,0.00001718022,0.000002403476,0.0001006265,0.00006643979,0.0000832772,0.9862317,0.0000910766,0.00003038576,0.00624758],"study_design_scores_gemma":[0.00002341924,0.0007094814,0.2610495,0.00001828783,0.00003391975,0.004559002,0.0002563345,0.003438901,0.7252844,0.000827828,0.003784862,0.00001417842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969041,0.0002266081,0.002047796,0.00001016534,0.000001617899,0.00000525241,0.00008999252,0.00004410675,0.0006702496],"genre_scores_gemma":[0.9971494,0.0001405889,0.001835005,0.0000172659,0.000005361698,0.00001032562,0.0002067633,0.00001404439,0.0006211677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040065,"threshold_uncertainty_score":0.003479362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006387020040411905,"score_gpt":0.2087188404559359,"score_spread":0.202331820415524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}