{"id":"W2077715783","doi":"10.1016/j.bmcl.2008.12.045","title":"Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre; Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; HDAC6; Moiety; Gene isoform; Selectivity; Histone deacetylase; Stereochemistry; Piperazine; Small molecule; Biochemistry; Histone; Gene; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447057,0.0005248674,0.0004572749,0.000258889,0.0002160489,0.0003402854,0.0006254998,0.0002801618,0.004110365],"category_scores_gemma":[0.0001149495,0.0001800345,0.000210443,0.0002634713,0.0001815482,0.0003001115,0.0003043375,0.0007661526,0.001099667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004996294,"about_ca_system_score_gemma":0.0002628601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005451436,"about_ca_topic_score_gemma":0.001968024,"domain_scores_codex":[0.9999008,0.00001179391,0.000005885446,0.00001669011,0.00002324414,0.00004165345],"domain_scores_gemma":[0.9999557,0.000005078372,0.000009456708,0.000004840625,0.000006908409,0.00001805288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008748532,0.0002360939,0.0003381931,0.000277398,0.00004930849,0.000340372,0.00005036538,0.001446955,0.9299958,0.006063804,0.003414245,0.05691259],"study_design_scores_gemma":[0.0003405131,0.001045025,0.0005584496,0.0000110517,0.000046141,0.0004837253,0.00001968848,0.002590875,0.9633318,0.0005067914,0.03103948,0.00002661888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8280098,0.01955579,0.06502649,0.001881603,0.001531106,0.0006006686,0.002739186,0.001961986,0.07869329],"genre_scores_gemma":[0.9546227,0.008086347,0.01601416,0.0005606742,0.0001536912,0.0001383444,0.001048147,0.0001049917,0.01927071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004110365,"threshold_uncertainty_score":0.01375055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508043549799046,"score_gpt":0.2478901298616038,"score_spread":0.2328096943636133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}