{"id":"W2077715783","doi":"10.1016/j.bmcl.2008.12.045","title":"Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre; Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; HDAC6; Moiety; Gene isoform; Selectivity; Histone deacetylase; Stereochemistry; Piperazine; Small molecule; Biochemistry; Histone; Gene; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003092462,0.0005689795,0.0004421575,0.00009814971,0.0003827351,0.00002108912,0.0006185942,0.0004147329,0.0001495409],"category_scores_gemma":[0.0004111887,0.0005836225,0.0002605789,0.0004557107,0.0008155337,0.00001250847,0.0002680532,0.0007029198,0.0000903596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000445191,"about_ca_system_score_gemma":0.0005559125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399202,"about_ca_topic_score_gemma":0.0000189369,"domain_scores_codex":[0.996589,0.00005456889,0.0005756394,0.001053681,0.0007267886,0.001000303],"domain_scores_gemma":[0.9982314,0.0000305919,0.0002148317,0.0007819365,0.0002035752,0.000537669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833419,0.0002159971,0.000156539,0.00007090766,0.0001048972,0.0001701181,0.0002233755,0.00000517026,0.9564812,0.000001445053,0.04224838,0.0001386182],"study_design_scores_gemma":[0.001902565,0.0001716289,0.0003511385,0.0000508373,0.00004259457,0.00138901,0.0001069495,0.00002004899,0.986944,0.00000130924,0.008402807,0.0006171321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931973,0.0008326147,0.001182195,0.002119458,0.0002743707,0.0003302709,0.00004248789,0.00009204693,0.001929272],"genre_scores_gemma":[0.9925232,0.00009691163,0.0007225602,0.001558317,0.001879346,0.00005705313,0.0003608707,0.0001282709,0.002673492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03384557,"threshold_uncertainty_score":0.9996615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508043549799046,"score_gpt":0.2478901298616038,"score_spread":0.2328096943636133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}