{"id":"W2077725411","doi":"10.1002/dmrr.964","title":"Leptin and endothelin‐1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease","year":2009,"lang":"en","type":"article","venue":"Diabetes/Metabolism Research and Reviews","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Leptin; Endothelin 1; Endothelin receptor; Myocyte; Muscle hypertrophy; Bosentan; Downregulation and upregulation; Leptin receptor; Endothelin receptor antagonist; Streptozotocin; Fibronectin; Umbilical vein; Medicine; Receptor; Diabetes mellitus; Biology; Extracellular matrix; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002308337,0.000254017,0.0006142798,0.0004132933,0.000298789,0.0001795291,0.0001501521,0.00008715886,0.00003454402],"category_scores_gemma":[0.002881922,0.0001975398,0.00006397702,0.0007065505,0.0004340718,0.0003525993,0.0001018727,0.0004120183,0.00005333666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002251812,"about_ca_system_score_gemma":0.00005040902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002257791,"about_ca_topic_score_gemma":0.000001903183,"domain_scores_codex":[0.9962292,0.001299897,0.0004601446,0.0008184706,0.0005365131,0.0006557269],"domain_scores_gemma":[0.9987323,0.0001683423,0.00008849816,0.0004141646,0.00008374477,0.0005128994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007338729,0.0001331986,0.005883627,0.0002525323,0.00000236554,0.00001554733,0.00006035593,0.000001043182,0.9845828,0.0005653554,0.0001775506,0.008252203],"study_design_scores_gemma":[0.002076799,0.0004115744,0.3401988,0.0009059936,0.00005228044,0.00001331257,0.00003782783,0.0007793813,0.5285442,0.00502253,0.1211451,0.000812282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8952801,0.1000291,0.000002084375,0.002583472,0.00004098444,0.001954663,0.00001674612,0.00003085335,0.00006199039],"genre_scores_gemma":[0.9815227,0.01691823,0.0001841702,0.0002345912,0.0001717609,0.0001561288,0.000008606563,0.00001863578,0.0007852028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4560387,"threshold_uncertainty_score":0.805544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03988870499488419,"score_gpt":0.3085453517263937,"score_spread":0.2686566467315095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}