{"id":"W2077725411","doi":"10.1002/dmrr.964","title":"Leptin and endothelin‐1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease","year":2009,"lang":"en","type":"article","venue":"Diabetes/Metabolism Research and Reviews","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Leptin; Endothelin 1; Endothelin receptor; Myocyte; Muscle hypertrophy; Bosentan; Downregulation and upregulation; Leptin receptor; Endothelin receptor antagonist; Streptozotocin; Fibronectin; Umbilical vein; Medicine; Receptor; Diabetes mellitus; Biology; Extracellular matrix; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190745,0.000244733,0.000198018,0.000224711,0.00007392177,0.0001605467,0.0001003558,0.0001978451,0.0007298879],"category_scores_gemma":[0.0001012259,0.0001135375,0.0001183374,0.0001056622,0.0001656771,0.0001360527,0.0001199706,0.0002347906,0.00007064189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687126,"about_ca_system_score_gemma":0.00007008464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001925696,"about_ca_topic_score_gemma":0.0002863109,"domain_scores_codex":[0.9999233,0.00002451866,0.000006511711,0.00001137975,0.00001923965,0.00001502983],"domain_scores_gemma":[0.9999381,0.00001022643,0.00002348246,0.000002616096,0.000006315145,0.00001919844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001455214,0.0001398191,0.006978652,0.0002223767,0.00003957204,0.001186423,0.00005140291,0.0000743613,0.9800325,0.0001674949,0.00008353595,0.009568621],"study_design_scores_gemma":[0.0003234355,0.003386959,0.5560213,0.0001243754,0.0002586948,0.009903093,0.000373471,0.001551008,0.4225759,0.0006797193,0.004776824,0.00002532082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808209,0.01741895,0.0007254728,0.00009277681,0.00002666029,0.000008915101,0.00003850698,0.000007170087,0.0008606868],"genre_scores_gemma":[0.9905708,0.007604238,0.0008298412,0.00006055623,0.00003169201,0.00001832083,0.00007229621,0.000002487296,0.0008097843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007298879,"threshold_uncertainty_score":0.002441704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03988870499488419,"score_gpt":0.3085453517263937,"score_spread":0.2686566467315095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}