{"id":"W2077726456","doi":"10.1016/j.bpj.2012.11.2451","title":"A Luminal Calcium Sensing Mutation of the Cardiac Ryanodine Receptor Diminishes Calcium Waves and Stress -Induced Ventricular Tachycardias in Calsequestrin Null Mice","year":2013,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor 2; Calsequestrin; Ryanodine receptor; Calcium; Internal medicine; Endocrinology; Mutation; Biology; Chemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005637726,0.001284252,0.0009064591,0.001539346,0.0005693787,0.0007499863,0.001104697,0.001839824,0.00489113],"category_scores_gemma":[0.0007785484,0.0008128494,0.0008034559,0.0003278383,0.001849245,0.0006332338,0.0006816357,0.002390648,0.0009788964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003826042,"about_ca_system_score_gemma":0.0004791848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009539792,"about_ca_topic_score_gemma":0.001845473,"domain_scores_codex":[0.9992273,0.0001174106,0.0001469429,0.000200381,0.0001930658,0.0001148774],"domain_scores_gemma":[0.9978119,0.0004582223,0.0008403967,0.0001490602,0.00008205372,0.0006583623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003255,0.00008136879,0.00009651953,0.00002564491,0.00001430891,0.0002425621,0.00004270738,0.0001051377,0.9981359,0.0003014103,0.00005852497,0.000570349],"study_design_scores_gemma":[0.0007447128,0.001150386,0.007007742,0.00006921639,0.0001755103,0.00262856,0.0002472287,0.004711985,0.9790463,0.0006247008,0.003521094,0.00007242824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881237,0.0004194786,0.008029799,0.0004780812,0.0001924102,0.00006200502,0.001014276,0.0005329757,0.001147318],"genre_scores_gemma":[0.9818152,0.0006227047,0.006335877,0.0002826836,0.0001442198,0.0001627929,0.0007993735,0.000811348,0.009025857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00489113,"threshold_uncertainty_score":0.01636243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521935322506332,"score_gpt":0.2612440407586351,"score_spread":0.2460246875335717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}