{"id":"W2077777987","doi":"10.1016/s0378-1119(01)00742-9","title":"A novel strategy for regulated expression of a cytotoxic gene","year":2001,"lang":"en","type":"article","venue":"Gene","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Barnase; Biology; Transactivation; Gene; Gene expression; Cytotoxic T cell; Molecular biology; Suicide gene; Mutant; Regulation of gene expression; Transgene; Promoter; Cell biology; Genetics; RNA; Genetic enhancement; In vitro; Ribonuclease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014595,0.00012775,0.0001442183,0.00005298986,0.00005387593,0.000009352308,0.0002154131,0.0001485192,0.00005342418],"category_scores_gemma":[0.00002943121,0.0001194784,0.00009942393,0.0001179381,0.00005475319,0.000002301601,0.00006532379,0.00004656913,0.000004549389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001161337,"about_ca_system_score_gemma":0.0001107593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009243717,"about_ca_topic_score_gemma":0.00003012283,"domain_scores_codex":[0.9990235,0.00003197772,0.0002010687,0.0003066538,0.0001463268,0.0002904832],"domain_scores_gemma":[0.9992499,0.000008896687,0.00007279574,0.0004446413,0.0001413859,0.00008236984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00241374,0.0001148084,0.00004749013,0.00001290705,0.00003472199,0.000001707788,0.00001333049,0.0007037449,0.9932492,0.000003554114,0.0004527443,0.002951987],"study_design_scores_gemma":[0.00144378,0.002038834,0.0002320216,0.000008485289,0.000007370598,0.00002136512,0.00001282192,0.000193799,0.9937734,0.000058866,0.002076421,0.0001328281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888907,0.0008688358,0.009571829,0.00005008949,0.00003760977,0.0003743113,0.00007093886,0.00001115934,0.000124545],"genre_scores_gemma":[0.9949032,0.0002393671,0.003151578,0.00007324199,0.0001940497,0.00006984975,0.0002209954,0.00003402967,0.001113694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006420251,"threshold_uncertainty_score":0.4872188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03782117441491499,"score_gpt":0.3204300083395106,"score_spread":0.2826088339245956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}