{"id":"W2077809631","doi":"10.1158/0008-5472.can-08-2169","title":"An Epigenetic Genome-Wide Screen Identifies <i>SPINT2</i> as a Novel Tumor Suppressor Gene in Pediatric Medulloblastoma","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Hospital for Sick Children","funders":"","keywords":"Cancer research; Biology; SOCS5; Tumor suppressor gene; Medulloblastoma; SOCS6; Epigenetics; Suppressor; Gene; DNA methylation; Carcinogenesis; Molecular biology; Genetics; Gene expression; SOCS3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007764411,0.0002430581,0.0002819655,0.0003218628,0.0003224701,0.00004739262,0.0007154187,0.0001445748,0.00007119129],"category_scores_gemma":[0.0004533705,0.0002476928,0.00008885927,0.0005930201,0.0003988441,0.00001166042,0.0003870733,0.0003563862,0.00008148486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009939258,"about_ca_system_score_gemma":0.0006785577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008413493,"about_ca_topic_score_gemma":0.0009799442,"domain_scores_codex":[0.9970393,0.0002277965,0.000365304,0.0008250242,0.0006376494,0.0009049706],"domain_scores_gemma":[0.9985051,0.00006744324,0.00006553317,0.0006873583,0.0004178415,0.0002567465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001604135,0.0001520772,0.03578042,0.0000505037,0.00003821759,0.0001082171,0.0003972362,0.000453087,0.961721,0.000003260791,0.001072196,0.00006336515],"study_design_scores_gemma":[0.0008924027,0.0005009518,0.1243319,0.00001952003,0.00001194513,0.00003440998,0.0001751768,0.00001886306,0.8699512,0.00003498325,0.003693669,0.0003349418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906599,0.007896702,0.0001750732,0.0001888691,0.0001271429,0.000482844,0.00009487037,0.00002356558,0.0003510651],"genre_scores_gemma":[0.9945487,0.002921328,0.0002233183,0.0002186392,0.000792041,0.0003716417,0.00006735527,0.00006690391,0.0007900106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09176978,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05550844363505932,"score_gpt":0.3559459815661001,"score_spread":0.3004375379310408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}