{"id":"W2077817920","doi":"10.1177/0091270008319792","title":"Pharmacokinetic Interaction Between Efavirenz and Carbamazepine After Multiple‐Dose Administration in Healthy Subjects","year":2008,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Carbamazepine; Efavirenz; Pharmacokinetics; Crossover study; Pharmacology; Confidence interval; Dosing; Pharmacokinetic interaction; Drug interaction; Active metabolite; Metabolite; Medicine; Chemistry; Internal medicine; Antiretroviral therapy; Epilepsy; Viral load; Human immunodeficiency virus (HIV); Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001272643,0.000544304,0.001825842,0.0002326595,0.0003539652,0.0005943156,0.0002550701,0.0008648619,0.001140488],"category_scores_gemma":[0.0021689,0.000552525,0.0005436471,0.0002579201,0.0005342657,0.0004529713,0.000177314,0.0009051011,0.0002376461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000529562,"about_ca_system_score_gemma":0.0005143336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001825552,"about_ca_topic_score_gemma":0.001769388,"domain_scores_codex":[0.998983,0.0004940301,0.00004593395,0.0002284349,0.0001612345,0.00008731799],"domain_scores_gemma":[0.99927,0.000251065,0.0001516388,0.00007328545,0.0000488626,0.0002051926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.556524,0.01638062,0.1406671,0.0004453553,0.002395496,0.001182573,0.0008566716,0.001508128,0.1671432,0.0002937312,0.001214174,0.1113888],"study_design_scores_gemma":[0.04399499,0.3160425,0.6151174,0.00002737423,0.001239133,0.002022212,0.0002009738,0.004946313,0.01316807,0.0003365956,0.002798781,0.0001055973],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985681,0.0006947871,0.000274099,0.00002609754,0.00002067208,0.00008749007,0.00007453386,0.00002079681,0.0002332944],"genre_scores_gemma":[0.9986473,0.0002329736,0.0004758798,0.0001119761,0.00004844682,0.00007930445,0.0001131445,0.000005121654,0.0002858369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825842,"threshold_uncertainty_score":0.006730497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0899044327554101,"score_gpt":0.4442458723768858,"score_spread":0.3543414396214757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}