{"id":"W2077818255","doi":"10.1038/cgt.2008.89","title":"High-dose chemotherapy augments the efficacy of recombinant adenovirus vaccines and improves the therapeutic outcome","year":2008,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Cancer Institute; Krebsliga Schweiz; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; McMaster University","keywords":"Antigen; Tumor antigen; Medicine; Immunology; Cancer research; Immunotherapy; Viral vector; Melanoma; Adenoviridae; Cytotoxic T cell; CD8; Virology; Recombinant DNA; Biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863746,0.0003441568,0.0004897073,0.0000730726,0.0006605558,0.00001882259,0.0006345212,0.0001745771,0.0004720306],"category_scores_gemma":[0.0000182952,0.0001732246,0.0001817237,0.000224077,0.0006751969,0.00008609772,0.00005560173,0.0003181729,0.00002704085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003989907,"about_ca_system_score_gemma":0.0001237937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005761852,"about_ca_topic_score_gemma":0.00000912314,"domain_scores_codex":[0.9982469,0.0004141782,0.0005141238,0.0003238188,0.00007526101,0.0004256978],"domain_scores_gemma":[0.9984033,0.0004538698,0.0003036392,0.0007407186,0.0000816782,0.00001680179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004390133,0.0002151716,0.003934793,0.00000693736,0.0009084647,0.000001380381,0.002636691,0.000004436072,0.8260091,0.0001129545,0.000695687,0.1610842],"study_design_scores_gemma":[0.008856107,0.0006319699,0.35465,0.00001970675,0.00004591604,0.00009297285,0.0001691182,0.000001631464,0.5708347,0.0001845472,0.0642358,0.00027755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8271106,0.1684402,0.00001804329,0.002228105,0.00149633,0.0006379944,0.00001029997,0.00004206903,0.0000163788],"genre_scores_gemma":[0.9121453,0.08134146,0.00001614218,0.002259893,0.00007549461,0.0001273509,0.000008576988,0.00004858373,0.003977256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3507152,"threshold_uncertainty_score":0.7063894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03104248164977965,"score_gpt":0.283242465940554,"score_spread":0.2521999842907743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}