{"id":"W2077818255","doi":"10.1038/cgt.2008.89","title":"High-dose chemotherapy augments the efficacy of recombinant adenovirus vaccines and improves the therapeutic outcome","year":2008,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Cancer Institute; Krebsliga Schweiz; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; McMaster University","keywords":"Antigen; Tumor antigen; Medicine; Immunology; Cancer research; Immunotherapy; Viral vector; Melanoma; Adenoviridae; Cytotoxic T cell; CD8; Virology; Recombinant DNA; Biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002950398,0.0002553507,0.0005420783,0.0003541147,0.0001297206,0.000478321,0.0002089042,0.0002959215,0.001650157],"category_scores_gemma":[0.000344953,0.0000967407,0.0001817226,0.0002128098,0.0003056979,0.0003301958,0.0001917605,0.000808047,0.0003329577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080789,"about_ca_system_score_gemma":0.0003080266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000270259,"about_ca_topic_score_gemma":0.0003671028,"domain_scores_codex":[0.9998581,0.0000406185,0.000007903415,0.00001843413,0.00003013184,0.00004480725],"domain_scores_gemma":[0.9997303,0.00009299954,0.00005233615,0.00005295469,0.00001736916,0.00005406281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.006666267,0.002843509,0.003536625,0.0002178277,0.00008527912,0.0001684475,0.00007205232,0.002717786,0.8678531,0.001825749,0.00211723,0.1118962],"study_design_scores_gemma":[0.001539485,0.02845957,0.05822841,0.00008543566,0.0003628215,0.001784604,0.0001306386,0.007418476,0.8739352,0.001731774,0.02626816,0.00005533623],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887022,0.005460631,0.001687549,0.0003381734,0.000103156,0.00004450233,0.0001271171,0.0001448673,0.003392003],"genre_scores_gemma":[0.9962191,0.001458206,0.0006657141,0.00006650783,0.00004305928,0.0000184068,0.0002195203,0.00002085104,0.001288602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650157,"threshold_uncertainty_score":0.005520344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03104248164977965,"score_gpt":0.283242465940554,"score_spread":0.2521999842907743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}