{"id":"W2077841072","doi":"10.1007/s002109900167","title":"Noradrenoceptor antagonism with idazoxan improves l-dopa-induced dyskinesias in MPTP monkeys","year":2000,"lang":"en","type":"article","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Medical Research Council; Les Laboratories Pierre Fabre; Université Laval","keywords":"Idazoxan; Benserazide; MPTP; Antagonist; Medicine; Dopamine; Parkinson's disease; Levodopa; Internal medicine; Endocrinology; Psychology; Pharmacology; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357999,0.0005609649,0.0008640144,0.0003811707,0.0004463322,0.0004910195,0.0006049457,0.0006473199,0.001958471],"category_scores_gemma":[0.0002764052,0.0002435215,0.0002593624,0.0001863894,0.0003610964,0.0004542219,0.000158117,0.001532106,0.0008765703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004196991,"about_ca_system_score_gemma":0.0004200421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002198725,"about_ca_topic_score_gemma":0.005611273,"domain_scores_codex":[0.9998878,0.00001658776,0.00001328297,0.00001736143,0.00001736408,0.00004758018],"domain_scores_gemma":[0.9998275,0.00002233535,0.00003173948,0.00002419282,0.00001412579,0.00008009541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01480274,0.003160144,0.001452137,0.0002851209,0.0001476184,0.0007066682,0.0001451013,0.0004769455,0.9515644,0.000458979,0.001525019,0.0252752],"study_design_scores_gemma":[0.00566728,0.03785384,0.03792881,0.0001276929,0.0005339239,0.002229539,0.000364556,0.006238737,0.8973271,0.0005855845,0.01104459,0.00009840107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949287,0.0009410492,0.0002615292,0.000239009,0.00008155706,0.00004604574,0.0005268668,0.0001312854,0.002843882],"genre_scores_gemma":[0.9949332,0.0007649678,0.0004200856,0.000106871,0.00003564407,0.00005541461,0.0007150245,0.00002610234,0.002942721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198725,"threshold_uncertainty_score":0.006551683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103750562094988,"score_gpt":0.2787782142821026,"score_spread":0.2677407086611527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}