{"id":"W2077883283","doi":"10.1021/bi000856g","title":"Determination of the Structure of <i>Escherichia coli</i> Glyoxalase I Suggests a Structural Basis for Differential Metal Activation","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Enzyme; Escherichia coli; Active site; Lactoylglutathione lyase; Methylglyoxal; Trigonal bipyramidal molecular geometry; Stereochemistry; Metal; Hydrolase; Biochemistry; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004118065,0.0003183296,0.0001442908,0.0001136216,0.0001185762,0.0003366239,0.0002827874,0.0002266664,0.0005361378],"category_scores_gemma":[0.0001114068,0.0001031958,0.0001561389,0.0001387111,0.0001798912,0.0001524422,0.0001001668,0.0003214393,0.0003217646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003657113,"about_ca_system_score_gemma":0.0001859491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008226599,"about_ca_topic_score_gemma":0.0006051585,"domain_scores_codex":[0.9999726,0.000005012776,0.000001765232,0.000009338317,0.000005811951,0.000005436369],"domain_scores_gemma":[0.9999243,0.00000712755,0.00003181253,0.000007504725,0.00001207122,0.00001716565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007493,0.00002588157,0.002099983,0.00006434274,0.000009262745,0.0001468587,0.00004377483,0.0005434867,0.991811,0.0007266946,0.0001540986,0.00417388],"study_design_scores_gemma":[0.00003374756,0.0006283132,0.03838894,0.0000233685,0.00003983616,0.001374017,0.0001789427,0.005070943,0.9384478,0.001072647,0.01471686,0.00002451082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874849,0.001104607,0.007810696,0.0002548446,0.00002157582,0.00002625928,0.000369906,0.0001144683,0.002812736],"genre_scores_gemma":[0.9896109,0.0005277192,0.007204737,0.00009392223,0.000007488936,0.00001113946,0.001389342,0.00001935826,0.001135422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008226599,"threshold_uncertainty_score":0.00265336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782483826149304,"score_gpt":0.271697943999919,"score_spread":0.263873105738426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}