{"id":"W2077939252","doi":"10.1021/ja993805j","title":"Nanomolar versus Millimolar Inhibition by Xylobiose-Derived Azasugars:  Significant Differences between Two Structurally Distinct Xylanases","year":2000,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Xylanase; Xylobiose; Stereochemistry; Steric effects; Residue (chemistry); Active site; Enzyme; Glucosidases; Bacillus circulans; Imidazole; Lactam; Oxime; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002100567,0.000364971,0.000294203,0.0001062771,0.00007895879,0.0003424356,0.0003050303,0.0003145642,0.0006955976],"category_scores_gemma":[0.0002053499,0.0001177639,0.0001300407,0.00009237514,0.0001973985,0.0001592426,0.0001267549,0.0005447706,0.0002479266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661316,"about_ca_system_score_gemma":0.0001418298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006735672,"about_ca_topic_score_gemma":0.0008827098,"domain_scores_codex":[0.9998171,0.00003782137,0.00001953169,0.00003239022,0.00005133038,0.00004183683],"domain_scores_gemma":[0.999884,0.000045011,0.00002455519,0.000007734506,0.00001536995,0.00002335211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004876565,0.00001549532,0.00007991205,0.00002047475,0.000003450819,0.00001100006,0.000009768639,0.00003033929,0.9991857,0.00004538503,0.000008042755,0.0005417325],"study_design_scores_gemma":[0.000005307385,0.0002022776,0.00139378,0.000002111426,0.000007319652,0.00008879897,0.00001421953,0.0003220882,0.9973833,0.00001984641,0.0005584569,0.000002439617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873587,0.004060138,0.005695549,0.0001054993,0.00003180914,0.00002781005,0.0001921739,0.00008112005,0.00244719],"genre_scores_gemma":[0.9941345,0.001001197,0.003466204,0.00005104546,0.000008406495,0.00002455624,0.0003011519,0.00001543467,0.0009976451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006955976,"threshold_uncertainty_score":0.002326965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360664933425497,"score_gpt":0.2338996480549559,"score_spread":0.2202929987207009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}