{"id":"W2078007153","doi":"10.1371/journal.pntd.0003391","title":"DNA-Protein Immunization Using Leishmania Peroxidoxin-1 Induces a Strong CD4+ T Cell Response and Partially Protects Mice from Cutaneous Leishmaniasis: Role of Fusion Murine Granulocyte-Macrophage Colony-Stimulating Factor DNA Adjuvant","year":2014,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Immunology; Leishmania; Adjuvant; Leishmaniasis; Granulocyte macrophage colony-stimulating factor; Biology; Immunization; DNA vaccination; Macrophage; Fusion protein; Leishmania major; Granulocyte; Virology; Immune system; Cytokine; Recombinant DNA; In vitro; Gene; Parasite hosting; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171939,0.0005844184,0.0002849824,0.0003106496,0.0001055546,0.0001924657,0.0002029496,0.0004679983,0.001061194],"category_scores_gemma":[0.00009860453,0.0001405688,0.0002788675,0.0001087908,0.000311665,0.0002171074,0.0001604568,0.001101833,0.0002956384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315111,"about_ca_system_score_gemma":0.0002005092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002028567,"about_ca_topic_score_gemma":0.0002739336,"domain_scores_codex":[0.9998671,0.00001917799,0.000008751399,0.00003024572,0.0000290404,0.00004570923],"domain_scores_gemma":[0.9998883,0.00001989908,0.00003550241,0.00001026416,0.00001099667,0.00003500991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002080473,0.0001521521,0.0001321111,0.00005324755,0.000003771374,0.00002921097,0.00001032676,0.0000463258,0.9985727,0.00003246717,0.00001828746,0.0007412931],"study_design_scores_gemma":[0.0001265816,0.003136536,0.002836619,0.00001584505,0.00002788021,0.0002976111,0.00002341145,0.0005376961,0.9919221,0.00004959408,0.001022034,0.00000409776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974144,0.0006514408,0.001067284,0.0001018212,0.00002934527,0.00004735917,0.0001239239,0.00005912358,0.0005052902],"genre_scores_gemma":[0.9957769,0.0005727556,0.001409006,0.00007276599,0.00002044093,0.00005370235,0.0004289001,0.00001081476,0.001654728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061194,"threshold_uncertainty_score":0.003550053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788095519180882,"score_gpt":0.2540689872969937,"score_spread":0.2361880321051849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}