{"id":"W2078007153","doi":"10.1371/journal.pntd.0003391","title":"DNA-Protein Immunization Using Leishmania Peroxidoxin-1 Induces a Strong CD4+ T Cell Response and Partially Protects Mice from Cutaneous Leishmaniasis: Role of Fusion Murine Granulocyte-Macrophage Colony-Stimulating Factor DNA Adjuvant","year":2014,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Immunology; Leishmania; Adjuvant; Leishmaniasis; Granulocyte macrophage colony-stimulating factor; Biology; Immunization; DNA vaccination; Macrophage; Fusion protein; Leishmania major; Granulocyte; Virology; Immune system; Cytokine; Recombinant DNA; In vitro; Gene; Parasite hosting; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00003413755,0.0005645405,0.001138352,0.0003179927,0.0004789375,0.0001251729,0.0002965557,0.0002477315,0.0001603308],"category_scores_gemma":[0.004252076,0.0005037643,0.0001874001,0.0005378082,0.000359132,0.0002772732,0.000413661,0.0005439027,0.00001237195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464245,"about_ca_system_score_gemma":0.0002866114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005270686,"about_ca_topic_score_gemma":0.0001104512,"domain_scores_codex":[0.9951887,0.001146364,0.0008765608,0.0008987456,0.001101016,0.0007885887],"domain_scores_gemma":[0.9968933,0.0008996978,0.0004191443,0.0006316148,0.0005925925,0.0005635956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00768681,0.001098105,0.02134563,0.0004540877,0.0002259594,0.0001289776,0.0005111963,0.00009558075,0.9666837,0.0000117604,0.000006300699,0.001751874],"study_design_scores_gemma":[0.002800451,0.001740904,0.5712098,0.00079159,0.0003632335,0.00001379012,0.0002656667,0.01504242,0.4073462,0.00006209489,0.00002057761,0.0003432942],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947797,0.001719399,0.0002875286,0.0001926444,0.00003996972,0.002452486,0.0002428827,0.0002454546,0.0000399431],"genre_scores_gemma":[0.9975366,0.00008585639,0.001697146,0.00005208946,0.000223282,0.0001480083,0.00009865811,0.0001136343,0.00004470937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5593375,"threshold_uncertainty_score":0.9997414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788095519180882,"score_gpt":0.2540689872969937,"score_spread":0.2361880321051849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}