{"id":"W2078028063","doi":"10.1107/s0907444907065572","title":"Modulation of activity by Arg407: structure of a fungal α-1,2-mannosidase in complex with a substrate analogue","year":2008,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University Health Centre; Hospital for Sick Children","funders":"National Institute of General Medical Sciences","keywords":"Mannosidase; Substrate (aquarium); Modulation (music); Chemistry; Stereochemistry; Biology; Biochemistry; Enzyme; Physics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591328,0.00044327,0.000409498,0.0001300731,0.0002685909,0.0004878169,0.0009158572,0.0005578179,0.001941988],"category_scores_gemma":[0.0002853353,0.0001721975,0.0002378175,0.0003907126,0.0002820494,0.0002840374,0.0001388669,0.0009208307,0.0002849566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008774252,"about_ca_system_score_gemma":0.0004052563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006195171,"about_ca_topic_score_gemma":0.002852306,"domain_scores_codex":[0.9998763,0.00001913921,0.000004632829,0.00002159222,0.00004252712,0.00003577832],"domain_scores_gemma":[0.9998673,0.00002989289,0.00003126844,0.000006110896,0.00001466954,0.00005078289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004175184,0.0006053786,0.0060993,0.0003627138,0.000207059,0.004178961,0.0004677133,0.01024008,0.9599937,0.002095752,0.003029547,0.008544602],"study_design_scores_gemma":[0.001099684,0.002307652,0.0725105,0.00009043857,0.000215734,0.003294514,0.0008253682,0.1452197,0.7574812,0.001300339,0.01547057,0.0001843542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972973,0.0006895974,0.000385244,0.0001577136,0.00002006796,0.00000466081,0.0003161085,0.00005901626,0.001070191],"genre_scores_gemma":[0.9953588,0.0007494036,0.001014414,0.00006118789,0.00001402815,0.000007534007,0.001834611,0.00003175907,0.0009282312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006195171,"threshold_uncertainty_score":0.01231819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145071117327081,"score_gpt":0.2441091580352058,"score_spread":0.222658446861935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}