{"id":"W2078061895","doi":"10.1089/hum.2011.157","title":"Enhanced Athletic Performance on Multisite AAV-IGF1 Gene Transfer Coincides with Massive Modification of the Muscle Proteome","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"World Anti-Doping Agency","keywords":"Genetic enhancement; Biology; Skeletal muscle; Adeno-associated virus; Muscle hypertrophy; Oxidative phosphorylation; Myocyte; Gene expression; Cell biology; Gene; Internal medicine; Endocrinology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006759712,0.0001506621,0.0001238044,0.00002361223,0.0001410707,0.000003472356,0.000222947,0.00009265875,0.00006898181],"category_scores_gemma":[0.000002636124,0.00009993339,0.00006848366,0.00005888604,0.0001870984,0.000004460052,0.00001592292,0.00007394134,0.000005975198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006136807,"about_ca_system_score_gemma":0.00002558403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002002078,"about_ca_topic_score_gemma":0.00001780182,"domain_scores_codex":[0.9992485,0.00006751676,0.0001501808,0.0002712706,0.00009623187,0.0001663185],"domain_scores_gemma":[0.9993612,0.000003723183,0.00006990262,0.000466937,0.00006895034,0.00002933664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006272258,0.000143942,0.0003629243,0.00001090027,0.00004444096,2.390468e-7,0.0006271987,0.0002058309,0.9957114,0.00006959505,0.000007746329,0.002188513],"study_design_scores_gemma":[0.0009031194,0.001024816,0.1629539,0.00001164742,0.00000712575,8.304544e-7,0.00002985526,0.00001991024,0.8347946,0.00007120486,0.00006200963,0.0001209197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975382,0.00018175,0.001043391,0.00002000862,0.00003012492,0.0005112505,0.000007025759,0.000009814396,0.0006584517],"genre_scores_gemma":[0.9989803,0.0002636094,0.0001910996,0.0002099019,0.00004465558,0.0001175809,0.00003455662,0.00002166827,0.0001366405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.162591,"threshold_uncertainty_score":0.4075165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02844181362903717,"score_gpt":0.2364630647022005,"score_spread":0.2080212510731634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}