{"id":"W2078061895","doi":"10.1089/hum.2011.157","title":"Enhanced Athletic Performance on Multisite AAV-IGF1 Gene Transfer Coincides with Massive Modification of the Muscle Proteome","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"World Anti-Doping Agency","keywords":"Genetic enhancement; Biology; Skeletal muscle; Adeno-associated virus; Muscle hypertrophy; Oxidative phosphorylation; Myocyte; Gene expression; Cell biology; Gene; Internal medicine; Endocrinology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002430187,0.0004766923,0.0003015185,0.0003248673,0.0001377131,0.0003634123,0.0002204451,0.0004370658,0.001301989],"category_scores_gemma":[0.00009234466,0.0001482167,0.0004751393,0.0001317128,0.0003166826,0.0002704962,0.0002181141,0.0006443322,0.0004698515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049137,"about_ca_system_score_gemma":0.000122663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003734204,"about_ca_topic_score_gemma":0.0005453876,"domain_scores_codex":[0.9998249,0.00001533658,0.00001411084,0.00005953067,0.00005425061,0.00003196638],"domain_scores_gemma":[0.999863,0.00001890194,0.00003919621,0.00001674398,0.00002693189,0.00003517281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006507453,0.00002127448,0.0001500713,0.00001689126,0.000004349875,0.00002300719,0.00001148829,0.0000155796,0.9979452,0.00003567756,0.00003333491,0.001677945],"study_design_scores_gemma":[0.00001357623,0.0005093177,0.008303404,0.000008025689,0.0000265142,0.0002206193,0.00002704481,0.0004628985,0.9882736,0.00006065359,0.00208678,0.000007534951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980332,0.002118817,0.01356052,0.0002785858,0.0001743617,0.00009074614,0.0003636676,0.0003532884,0.00272798],"genre_scores_gemma":[0.980539,0.001434018,0.008229863,0.0001986418,0.000036449,0.0001029456,0.0004222756,0.00005757181,0.008979153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301989,"threshold_uncertainty_score":0.004355609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02844181362903717,"score_gpt":0.2364630647022005,"score_spread":0.2080212510731634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}