{"id":"W2078069375","doi":"10.1038/onc.2010.137","title":"The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; College of Medicine, University of Florida; Canadian Institutes of Health Research; University of Florida; Howard Hughes Medical Institute","keywords":"Oncolytic virus; Biology; Myxoma virus; Carcinogenesis; Tropism; Tissue tropism; Tumor suppressor gene; Suppressor; Oncogene; Virus; Cancer research; Virology; Cancer; Cancer cell; Viral replication; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827057,0.000339114,0.0002464922,0.0003164833,0.0001746997,0.0005190087,0.0001777912,0.0003211171,0.0007566257],"category_scores_gemma":[0.000532225,0.0002205197,0.0002021208,0.0001108629,0.000346281,0.000476813,0.0003342971,0.0005653737,0.0002927018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786193,"about_ca_system_score_gemma":0.0001482838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003263717,"about_ca_topic_score_gemma":0.00033438,"domain_scores_codex":[0.9997638,0.00006028561,0.00001572371,0.00003542116,0.00005142667,0.00007329587],"domain_scores_gemma":[0.9996399,0.0001567748,0.00006104616,0.00003599427,0.00003425406,0.00007215669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008233268,0.000005566974,0.0002522419,0.000005548906,0.000001456115,0.00001688133,0.00002031448,0.00003842426,0.9991581,0.0001503782,0.000007061935,0.0002616617],"study_design_scores_gemma":[0.00001423253,0.0002851678,0.00613436,0.00000375282,0.00001241978,0.0006986663,0.00009055025,0.00150049,0.9901999,0.0001562752,0.0008944796,0.000009690598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970399,0.0006080186,0.00136307,0.0000379667,0.0000108291,0.000005879368,0.00005214157,0.00001908996,0.0008631289],"genre_scores_gemma":[0.9982468,0.0002570673,0.0007787386,0.00001926007,0.000005785549,0.00001173226,0.0001404039,0.00001923764,0.0005209293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007566257,"threshold_uncertainty_score":0.002531171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000978060619766,"score_gpt":0.2841229345933439,"score_spread":0.2741131539871462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}