{"id":"W2078069375","doi":"10.1038/onc.2010.137","title":"The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; College of Medicine, University of Florida; Canadian Institutes of Health Research; University of Florida; Howard Hughes Medical Institute","keywords":"Oncolytic virus; Biology; Myxoma virus; Carcinogenesis; Tropism; Tissue tropism; Tumor suppressor gene; Suppressor; Oncogene; Virus; Cancer research; Virology; Cancer; Cancer cell; Viral replication; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004384497,0.0003338105,0.0003205137,0.00005487044,0.0002863366,0.00007011428,0.0005118648,0.0001821281,0.000120314],"category_scores_gemma":[0.000107091,0.0002656702,0.0001397897,0.0001535376,0.0004945041,0.000009067279,0.0002700356,0.0003127829,0.00002246613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003553628,"about_ca_system_score_gemma":0.0002594453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005675353,"about_ca_topic_score_gemma":0.0009940175,"domain_scores_codex":[0.9976121,0.0001909561,0.0004523216,0.0006168187,0.0004191737,0.0007086357],"domain_scores_gemma":[0.9982454,0.00005953269,0.0002028358,0.001039154,0.0001628539,0.0002902805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001569073,0.0001431059,0.0007847458,0.00001417139,0.0001437079,0.00001508888,0.00004045327,0.000006762731,0.9908593,0.00001321605,0.002790522,0.003619887],"study_design_scores_gemma":[0.001781401,0.001513647,0.0003579537,0.000005356877,0.00004047153,0.00001425792,0.000009383546,0.0002926726,0.9263924,0.00009327065,0.06920732,0.0002918403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934636,0.004762285,0.00009194727,0.0001572192,0.0001987185,0.0004403055,0.0006827865,0.00002108923,0.0001820211],"genre_scores_gemma":[0.9974138,0.0005905568,0.0002935755,0.0003394276,0.0002707315,0.00005333927,0.0001504675,0.00008487935,0.0008032089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0664168,"threshold_uncertainty_score":0.9999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000978060619766,"score_gpt":0.2841229345933439,"score_spread":0.2741131539871462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}