{"id":"W2078081719","doi":"10.1074/jbc.m113.523019","title":"Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; BRD4; Acetylation; Histone; Histone H4; Chemistry; Transcription factor; Cell biology; Biology; Biochemistry; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005847704,0.0001318447,0.0002149036,0.00001145024,0.00009090777,0.00002033397,0.0002492352,0.0001253704,0.00003496238],"category_scores_gemma":[0.0003762918,0.00005913658,0.0001191664,0.00004990368,0.000555441,0.000004796438,0.0001014061,0.0002873271,9.857972e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000138122,"about_ca_system_score_gemma":0.00004754152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005245317,"about_ca_topic_score_gemma":0.000004029004,"domain_scores_codex":[0.9991208,0.0001592594,0.0003238786,0.0001466744,0.0001229452,0.0001264994],"domain_scores_gemma":[0.9990488,0.00006785344,0.0004477175,0.0002112501,0.0001534513,0.00007092321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006095596,0.00007400755,0.0001101253,0.00002164113,0.00004557309,0.000001651277,0.0000241801,0.000004752373,0.9971358,0.00006574535,0.001511953,0.0003949722],"study_design_scores_gemma":[0.001201236,0.0003687886,0.0001734312,0.00003934999,0.00002012984,0.00009864311,0.0001469473,0.00002274987,0.9770454,0.0001459956,0.02064148,0.00009587262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942503,0.0005543227,0.001437909,0.002841479,0.00004222065,0.0001415416,0.00000528307,0.000003818037,0.0007231454],"genre_scores_gemma":[0.9982443,0.00003560156,0.0006511273,0.0001970745,0.0003266351,0.0000127457,0.000008795435,0.000007271017,0.0005164156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02009046,"threshold_uncertainty_score":0.241152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113704390261365,"score_gpt":0.2275832565024731,"score_spread":0.2164462125998594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}