{"id":"W2078081719","doi":"10.1074/jbc.m113.523019","title":"Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; BRD4; Acetylation; Histone; Histone H4; Chemistry; Transcription factor; Cell biology; Biology; Biochemistry; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011877,0.000281905,0.0001994714,0.0002460953,0.000158481,0.0001384153,0.0003391045,0.000268916,0.001375668],"category_scores_gemma":[0.0001971298,0.0001943639,0.0002265486,0.0001373858,0.0001224155,0.0001386713,0.0001735958,0.0003070684,0.000347177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003822813,"about_ca_system_score_gemma":0.00009672594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001666205,"about_ca_topic_score_gemma":0.001181039,"domain_scores_codex":[0.9998443,0.00002953786,0.000006708031,0.00003334682,0.00004810113,0.00003792086],"domain_scores_gemma":[0.999891,0.00004405299,0.00002064104,0.000005132187,0.00001725031,0.00002189074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007889925,0.00001908153,0.0004334777,0.0000165209,0.000008355325,0.00002397532,0.000007896273,0.00009504493,0.9988974,0.00002185127,0.00002011966,0.0003772127],"study_design_scores_gemma":[0.00002789723,0.0002541066,0.01845274,0.000005471561,0.00002792385,0.0003021634,0.00005276514,0.007621986,0.9716314,0.00005617511,0.001554121,0.00001326996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970683,0.0005625183,0.001576356,0.00004681693,0.00000541905,0.000006645286,0.0001207729,0.00001779911,0.0005953468],"genre_scores_gemma":[0.9963994,0.0002880005,0.001831854,0.00005023056,0.000002968319,0.000008481759,0.0003502073,0.000009851979,0.001058917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666205,"threshold_uncertainty_score":0.004602075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113704390261365,"score_gpt":0.2275832565024731,"score_spread":0.2164462125998594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}