{"id":"W2078095517","doi":"10.1016/j.vetimm.2008.09.024","title":"Somatic hypermutations and isotype restricted exceptionally long CDR3H contribute to antibody diversification in cattle","year":2008,"lang":"en","type":"article","venue":"Veterinary Immunology and Immunopathology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Food and Agriculture; University of Guelph","keywords":"Biology; Somatic cell; Isotype; Diversification (marketing strategy); Antibody; Genetics; Somatic hypermutation; Gene; B cell; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004927078,0.000266246,0.0002518261,0.0006803348,0.0003012593,0.0005085762,0.0003498514,0.0007705255,0.001292998],"category_scores_gemma":[0.0005796192,0.0002294645,0.0002008415,0.0003715547,0.000551722,0.000233231,0.0002611781,0.0005496513,0.0002012118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003224335,"about_ca_system_score_gemma":0.0001827884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008920378,"about_ca_topic_score_gemma":0.00127343,"domain_scores_codex":[0.9997,0.00008030454,0.00001761854,0.00005328387,0.00004591119,0.000102984],"domain_scores_gemma":[0.99955,0.0001988316,0.0001291991,0.00002746886,0.00002212685,0.00007233527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001972862,0.0001445477,0.1909758,0.0001027916,0.00014957,0.003839732,0.0004328687,0.001169016,0.7775337,0.0008807266,0.0002616452,0.02253668],"study_design_scores_gemma":[0.00009644818,0.000522732,0.9117001,0.00004527714,0.0002157009,0.0195333,0.0006190697,0.003610771,0.05895403,0.001423959,0.003245729,0.00003290083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989785,0.000295161,0.0002431988,0.00002848897,0.000002607068,0.000001817259,0.00003171274,0.000005826963,0.0004127308],"genre_scores_gemma":[0.9993947,0.0001075506,0.0001555414,0.00002843004,0.000009143499,0.000001628447,0.00003879978,0.000005769532,0.0002585652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292998,"threshold_uncertainty_score":0.004325509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024645379205805,"score_gpt":0.2545378744711725,"score_spread":0.2342914206791145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}