{"id":"W2078253671","doi":"10.1177/1087057111415525","title":"Discovery of Novel P2Y14 Agonist and Antagonist Using Conventional and Nonconventional Methods","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Agonist; Antagonist; Pharmacology; Chemistry; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311447,0.0006721177,0.0006464475,0.0005452699,0.0001889985,0.0005242987,0.0006884289,0.0006523211,0.002011328],"category_scores_gemma":[0.0002667763,0.000286801,0.0005458994,0.0003873253,0.000206812,0.0004415216,0.0005679368,0.0009997193,0.0009218846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354262,"about_ca_system_score_gemma":0.0003312448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971021,"about_ca_topic_score_gemma":0.0009254188,"domain_scores_codex":[0.9997681,0.00003919855,0.00001687028,0.00003964957,0.00008331121,0.00005286581],"domain_scores_gemma":[0.9999386,0.000008422762,0.00001297409,0.000005924193,0.00001767519,0.00001638811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003837665,0.0004460994,0.0004139529,0.0009173183,0.0001011532,0.0008888293,0.00008398269,0.0005210824,0.9289392,0.002403627,0.002148691,0.06275228],"study_design_scores_gemma":[0.0008985598,0.009343971,0.004076103,0.0001584773,0.0003347631,0.005047667,0.0001663044,0.00512041,0.8210241,0.001339075,0.1523634,0.0001272944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7214126,0.1093887,0.1178821,0.004040679,0.001243279,0.003053067,0.002722675,0.001015408,0.03924156],"genre_scores_gemma":[0.8216124,0.0671869,0.07398789,0.003868687,0.0003629572,0.001667663,0.003223259,0.00008827652,0.02800189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011328,"threshold_uncertainty_score":0.00672859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.047584850000515,"score_gpt":0.3200874059238605,"score_spread":0.2725025559233455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}