{"id":"W2078253671","doi":"10.1177/1087057111415525","title":"Discovery of Novel P2Y14 Agonist and Antagonist Using Conventional and Nonconventional Methods","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Agonist; Antagonist; Pharmacology; Chemistry; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084695,0.0001476939,0.0001771409,0.00004260122,0.00009093027,0.00004766894,0.00008141168,0.00009417371,0.00001789506],"category_scores_gemma":[0.00002954927,0.0001390285,0.00009289347,0.00005148233,0.0003021692,0.00003847084,0.0001652389,0.00006305283,3.355273e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006645062,"about_ca_system_score_gemma":0.00009288164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001061877,"about_ca_topic_score_gemma":0.000004797904,"domain_scores_codex":[0.999149,0.00004619236,0.0002454312,0.0003015581,0.0001007221,0.0001571464],"domain_scores_gemma":[0.9996049,0.00002284926,0.0001322827,0.0001518236,0.00004299391,0.0000451986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002519605,0.0002393636,0.02485904,0.0001004817,0.0002027449,0.000005046469,0.00007601516,0.00001378355,0.9541525,0.01957316,0.000320469,0.0002054646],"study_design_scores_gemma":[0.003480371,0.0005684661,0.04541972,0.0001611947,0.0002669533,0.0003578889,0.0005681753,0.001024893,0.9410978,0.002893891,0.00335825,0.0008023668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8638922,0.002394615,0.1324807,0.0000155069,0.0001592506,0.00007893197,0.0001014943,0.000003843868,0.0008734654],"genre_scores_gemma":[0.9765121,0.0001356523,0.02224579,0.00006715314,0.0001644911,0.000004413407,0.00009956679,0.0000177673,0.0007531143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1126198,"threshold_uncertainty_score":0.5669416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.047584850000515,"score_gpt":0.3200874059238605,"score_spread":0.2725025559233455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}