{"id":"W2078259659","doi":"10.1002/stem.578","title":"PRC2 Complexes with JARID2, MTF2, and esPRC2p48 in ES Cells to Modulate ES Cell Pluripotency and Somatic Cell Reprograming","year":2010,"lang":"en","type":"article","venue":"Stem Cells","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"American Heart Association; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"PRC2; Reprogramming; Biology; Induced pluripotent stem cell; Embryonic stem cell; KLF4; Cell biology; Cellular differentiation; Somatic cell; SOX2; Stem cell; Molecular biology; Histone H3; Histone; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870041,0.0004943449,0.0002853612,0.0002161979,0.0002136625,0.0004082875,0.0002804651,0.0002584316,0.001298011],"category_scores_gemma":[0.0001179433,0.0003252473,0.0003229826,0.0001808078,0.0002290459,0.0002851934,0.0004392368,0.0005205126,0.000485317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004292144,"about_ca_system_score_gemma":0.0001829347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004194503,"about_ca_topic_score_gemma":0.0008518849,"domain_scores_codex":[0.9996939,0.00004170086,0.00004137011,0.00009779318,0.00008513663,0.00004020676],"domain_scores_gemma":[0.9999322,0.000005517314,0.00002211698,0.00001055801,0.000006757543,0.00002279003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005479965,0.000007563436,0.00010145,0.00002777548,0.000006507436,0.00002541871,0.00001052368,0.0000462301,0.9989791,0.00007037233,0.00004060361,0.0006296735],"study_design_scores_gemma":[0.00001781366,0.0000619338,0.002162518,0.000003443549,0.00001550761,0.0001324871,0.00001332614,0.0008862577,0.9936499,0.00002513248,0.003028538,0.0000031804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778289,0.005534403,0.01090674,0.0002622991,0.0001077046,0.00006684856,0.000799619,0.000302102,0.004191335],"genre_scores_gemma":[0.9879693,0.001164959,0.003817064,0.00006886055,0.00001757523,0.00007181372,0.001000031,0.00005319578,0.005837295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298011,"threshold_uncertainty_score":0.004342258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005801621898991511,"score_gpt":0.213161101631057,"score_spread":0.2073594797320655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}