{"id":"W2078283036","doi":"10.4161/epi.6.12.18206","title":"Dramatic replacement of histone variants during genome remodeling in nuclear-transferred embryos","year":2011,"lang":"en","type":"article","venue":"Epigenetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Windsor","keywords":"Biology; Histone; Chromatin; Totipotent; Histone H3; Chromatin remodeling; Cell biology; Genetics; Embryo; Histone methylation; Somatic cell; Histone H2A; Zygote; Genome; Pronucleus; DNA; Embryonic stem cell; Embryogenesis; DNA methylation; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176719,0.0002121299,0.0001868488,0.0001615566,0.0001288004,0.0003076422,0.0003212873,0.0002960519,0.0008438581],"category_scores_gemma":[0.0002499019,0.0001802824,0.0002060047,0.0001107651,0.000279542,0.0002270685,0.0002967773,0.0005794893,0.0002802382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249828,"about_ca_system_score_gemma":0.0001638973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005251572,"about_ca_topic_score_gemma":0.0006752351,"domain_scores_codex":[0.999862,0.00001745761,0.00001374849,0.00004204333,0.00004262965,0.00002217625],"domain_scores_gemma":[0.9998258,0.00004552737,0.00004953216,0.00002687419,0.00001860859,0.0000336957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003334218,0.000003421867,0.0001692894,0.000007380013,0.00000258109,0.00007269121,0.00001547546,0.00002072237,0.9991222,0.00005327756,0.000003549682,0.0004960817],"study_design_scores_gemma":[0.00001165121,0.0001145795,0.01049029,0.000004055765,0.00001617044,0.0005924545,0.00005472495,0.0005611552,0.9869536,0.0000628995,0.00113169,0.00000682609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931222,0.0006603737,0.004888027,0.00002708445,0.00002647688,0.00002209223,0.0001704783,0.00006639016,0.001016883],"genre_scores_gemma":[0.9943255,0.0003408633,0.002621853,0.00004030093,0.000006153634,0.00002495921,0.0003124143,0.0000483732,0.002279637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008438581,"threshold_uncertainty_score":0.002822995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436991712986762,"score_gpt":0.2858795564415654,"score_spread":0.2715096393116977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}