{"id":"W2078298588","doi":"10.1210/me.2007-0268","title":"Nuclear Stabilization of β-Catenin and Inactivation of Glycogen Synthase Kinase-3β by Gonadotropin-Releasing Hormone: Targeting Wnt Signaling in the Pituitary Gonadotrope","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Astellas Foundation for Research on Metabolic Disorders","keywords":"Wnt signaling pathway; Biology; Cell biology; GSK-3; Signal transduction; LRP6; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002862683,0.000178892,0.0002209715,0.0001162731,0.00006609326,0.000009349228,0.000216284,0.0001277676,0.00001120609],"category_scores_gemma":[0.0001464578,0.0001623504,0.00005872608,0.0002069694,0.0001814327,0.000009921818,0.0001033618,0.0001398383,7.00304e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003341364,"about_ca_system_score_gemma":0.00004653147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001295266,"about_ca_topic_score_gemma":0.000006954026,"domain_scores_codex":[0.9985087,0.0001584378,0.0004681707,0.0003315272,0.0001793336,0.0003538108],"domain_scores_gemma":[0.9994016,0.00004539385,0.0002166799,0.0001832705,0.0001160199,0.00003703027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002263736,0.00007569215,0.001692245,0.00003475699,0.00004686426,0.0000209164,0.0002437726,0.0001857432,0.994583,0.0005854311,0.0001311965,0.002174025],"study_design_scores_gemma":[0.0007093682,0.0002700778,0.004106378,0.00002624723,0.00002651972,0.000021373,0.000606099,0.00004539522,0.9925742,0.0001458322,0.001282383,0.0001861259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883466,0.004869846,0.006225186,0.0001318103,0.00005004432,0.000234285,0.000008258618,0.000008963778,0.0001249876],"genre_scores_gemma":[0.9977649,0.0004368162,0.001430751,0.0001530299,0.00003252664,0.00001173234,0.000132359,0.00002966074,0.000008196151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009418311,"threshold_uncertainty_score":0.6620456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0058678481036225,"score_gpt":0.2262372384646216,"score_spread":0.2203693903609991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}