{"id":"W2078345391","doi":"10.1016/j.taap.2014.03.002","title":"Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs","year":2014,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology; Valeant Pharmaceuticals International; Takeda Science Foundation","keywords":"PEGylation; PEG ratio; Chemistry; In vivo; Polyethylene glycol; Liposome; Nanocarriers; Pharmacology; Biochemistry; Drug delivery; Medicine; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003609739,0.0003318688,0.000111542,0.0001876011,0.0001047183,0.0002253136,0.0003104317,0.0003494251,0.0005407904],"category_scores_gemma":[0.000323567,0.0001224543,0.0002000304,0.0001190602,0.0001808714,0.0001901198,0.0001764944,0.0004642124,0.0001898899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003371562,"about_ca_system_score_gemma":0.0001458619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004096319,"about_ca_topic_score_gemma":0.0003763872,"domain_scores_codex":[0.9998301,0.00002746118,0.0000189798,0.0000313029,0.00005098923,0.0000410992],"domain_scores_gemma":[0.999856,0.00002411266,0.00004679419,0.0000207511,0.00002883036,0.00002344781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003401783,0.00001604125,0.00005851953,0.00001020953,0.000001988223,0.00001084062,0.000006518729,0.00004746057,0.9990497,0.00005220599,0.00001690183,0.0006955092],"study_design_scores_gemma":[0.000005401409,0.00008247803,0.0003363915,8.789047e-7,0.000005572469,0.00004931497,0.000003223896,0.0002805263,0.9985433,0.00001123075,0.0006806453,0.000001137985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801244,0.0006431512,0.01735685,0.0001157336,0.00002802035,0.00007436663,0.0002531478,0.00008801492,0.001316287],"genre_scores_gemma":[0.9869798,0.0004186129,0.009093667,0.0001224337,0.00001041371,0.0000745287,0.0006205867,0.00003053889,0.0026493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005407904,"threshold_uncertainty_score":0.002446234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861720932842313,"score_gpt":0.2898725912968863,"score_spread":0.2612553819684631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}