{"id":"W2078408096","doi":"10.1021/jm100481d","title":"6-(3,4-Dichlorophenyl)-1-[(Methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: A New Potent and Selective Triple Reuptake Inhibitor","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Chemistry; Pharmacophore; Reuptake inhibitor; Pharmacology; In vivo; Antidepressant; Stereochemistry; Receptor; Biochemistry; Serotonin; Internal medicine; Hippocampus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006186397,0.0002528862,0.000277286,0.0001715655,0.0001396273,0.0001257866,0.0002285766,0.0001854707,0.00184589],"category_scores_gemma":[0.00004176121,0.0001043342,0.00007715692,0.0001357123,0.0001455421,0.000149235,0.0001964089,0.0003775683,0.0005502661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522779,"about_ca_system_score_gemma":0.0003552157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180772,"about_ca_topic_score_gemma":0.002628329,"domain_scores_codex":[0.9999564,0.000007260644,0.000002137979,0.000008146858,0.00001032435,0.00001568758],"domain_scores_gemma":[0.9999789,0.00000245619,0.000003990911,0.000001138674,0.000003312427,0.00001026928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003621948,0.00008692646,0.0001657895,0.0001387513,0.000006662586,0.0001513876,0.00003259089,0.0005019978,0.9858801,0.00059639,0.0002768306,0.01180045],"study_design_scores_gemma":[0.0002018335,0.002908813,0.003532768,0.00001587437,0.00002476058,0.0007909452,0.00004801909,0.002160237,0.9748209,0.0001990067,0.01526693,0.00002985696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973483,0.007340417,0.00743864,0.0003603194,0.00009496723,0.0001521685,0.0005938238,0.0001936692,0.01034297],"genre_scores_gemma":[0.9832287,0.003821442,0.005253849,0.0001229528,0.00002531418,0.00009017416,0.0005122633,0.00001504951,0.006930278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184589,"threshold_uncertainty_score":0.00617516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028701062865879,"score_gpt":0.2733399667348131,"score_spread":0.2630529561061543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}