{"id":"W2078408096","doi":"10.1021/jm100481d","title":"6-(3,4-Dichlorophenyl)-1-[(Methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: A New Potent and Selective Triple Reuptake Inhibitor","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Chemistry; Pharmacophore; Reuptake inhibitor; Pharmacology; In vivo; Antidepressant; Stereochemistry; Receptor; Biochemistry; Serotonin; Internal medicine; Hippocampus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004434555,0.0003102978,0.000699522,0.0001190363,0.00009210918,0.00003237403,0.0001570927,0.0002071786,0.0003354032],"category_scores_gemma":[0.001729414,0.000233568,0.0002505986,0.0002744448,0.0001923353,0.000148562,0.00005011548,0.001413138,0.000004249217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006688755,"about_ca_system_score_gemma":0.0008325215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001609324,"about_ca_topic_score_gemma":0.000004228303,"domain_scores_codex":[0.9977942,0.00004247286,0.0007440756,0.0003263123,0.000774477,0.000318494],"domain_scores_gemma":[0.9974582,0.0001654026,0.0004625545,0.0002891994,0.0005405341,0.00108417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001494036,0.0002825997,0.004468779,0.0001657217,0.0001530915,0.0009332232,0.0003188774,8.345568e-7,0.9661958,0.00000364614,0.01639136,0.00959207],"study_design_scores_gemma":[0.007764218,0.0009559721,0.02283947,0.0004339395,0.0007928404,0.009270187,0.0005184055,0.00003475017,0.9378132,0.0001885931,0.01907904,0.0003094411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917493,0.002716802,0.00008131619,0.003602451,0.0006190796,0.0001640225,0.00001013306,0.00002216749,0.001034763],"genre_scores_gemma":[0.9890165,0.0003824848,0.001288229,0.001143381,0.006196847,0.000003502365,0.00001000482,0.0000397346,0.001919335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02838262,"threshold_uncertainty_score":0.9524627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028701062865879,"score_gpt":0.2733399667348131,"score_spread":0.2630529561061543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}