{"id":"W2078425378","doi":"10.1371/journal.pone.0054295","title":"Down-Regulation of CTLA-4 by HIV-1 Nef Protein","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute on Drug Abuse; National Institutes of Health; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Endosome; Cell biology; Regulator; Biology; Cell; Chemistry; Intracellular; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269238,0.0002655456,0.0002292701,0.0001764723,0.0001396708,0.000345611,0.0002473097,0.0002312666,0.0007286279],"category_scores_gemma":[0.0001620588,0.0001066225,0.000245163,0.00008929524,0.0002536287,0.0001638773,0.0001771082,0.0005975201,0.0002081221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899755,"about_ca_system_score_gemma":0.0001921024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007008537,"about_ca_topic_score_gemma":0.0008567411,"domain_scores_codex":[0.9998608,0.00002604703,0.0000144763,0.00002123898,0.0000374902,0.00003993132],"domain_scores_gemma":[0.9999101,0.00003495036,0.00001622304,0.00001712636,0.00001010849,0.00001146278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004926918,0.00002480472,0.00009167044,0.00001473657,0.000002914517,0.00002989564,0.000005473284,0.00003851963,0.9984823,0.00009911739,0.0000159689,0.001145428],"study_design_scores_gemma":[0.000006940978,0.0001066024,0.001112692,0.000002015118,0.000006796849,0.0001109526,0.000007663228,0.0005225032,0.9970378,0.00002486841,0.001059813,0.000001511744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945158,0.001552102,0.002305223,0.00009030409,0.000035007,0.00001721041,0.0001233915,0.00004707617,0.001313812],"genre_scores_gemma":[0.9951073,0.0007196532,0.002185562,0.00004366789,0.000009851682,0.00002109137,0.0002184536,0.00001796473,0.001676578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007286279,"threshold_uncertainty_score":0.002829492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055574031026085,"score_gpt":0.2136952237655043,"score_spread":0.1931394834552434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}