{"id":"W2078426406","doi":"10.1042/bj20071264","title":"Cholesterol binding is a prerequisite for the activity of the steroidogenic acute regulatory protein (StAR)","year":2008,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Steroidogenic acute regulatory protein; Cholesterol; Helix (gastropod); Chemistry; Circular dichroism; Biochemistry; Stereochemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004320757,0.0004885715,0.001187776,0.0002348244,0.0005814302,0.0006300002,0.0003453008,0.0007469264,0.001748352],"category_scores_gemma":[0.0009002442,0.0003530182,0.0005517929,0.0002375612,0.0005135914,0.000403203,0.0005561336,0.0006359554,0.002635957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005818113,"about_ca_system_score_gemma":0.0004776492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350127,"about_ca_topic_score_gemma":0.0012851,"domain_scores_codex":[0.9993482,0.0001113801,0.00007321378,0.0001202092,0.0002264732,0.0001205037],"domain_scores_gemma":[0.9992126,0.0001795873,0.0001396668,0.00009490933,0.0001931226,0.0001800242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001447899,0.00003621322,0.001198352,0.0001475332,0.00001248573,0.0002077274,0.00004325241,0.00008885395,0.9950812,0.0004508803,0.0001539684,0.002434758],"study_design_scores_gemma":[0.00002779404,0.0003333474,0.0174717,0.00002189855,0.00002289295,0.001778268,0.00006799285,0.001712238,0.9655241,0.0007698522,0.01224293,0.00002697665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962069,0.007625197,0.02345977,0.0006101551,0.0001643391,0.0001555297,0.0007194058,0.0005053105,0.004691207],"genre_scores_gemma":[0.9838408,0.001421191,0.008568029,0.0001854772,0.00006528483,0.0000814946,0.002110409,0.00006283454,0.003664448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748352,"threshold_uncertainty_score":0.005848825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591814333418855,"score_gpt":0.251318713247458,"score_spread":0.2354005699132695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}