{"id":"W2078429697","doi":"10.1021/bi700817g","title":"Carboxyl-Terminal Disulfide Bond of Acid Sphingomyelinase Is Critical for Its Secretion and Enzymatic Function","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"","keywords":"Chinese hamster ovary cell; Endoplasmic reticulum; Mutant; Acid sphingomyelinase; Biochemistry; Sphingomyelin; Biology; Transfection; Wild type; Endoplasmic-reticulum-associated protein degradation; Ceramide; Secretion; Molecular biology; Mutant protein; Sphingomyelin phosphodiesterase; Cell biology; Gene; Unfolded protein response; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809119,0.0001120751,0.000186821,0.00004667418,0.00005405946,0.00001148514,0.00004841716,0.0001515057,0.00008002736],"category_scores_gemma":[0.0009079038,0.0001069126,0.00006921626,0.0001025748,0.0001212203,0.00004307811,0.00003540047,0.0001230148,0.000003640192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005621027,"about_ca_system_score_gemma":0.00007548872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008909102,"about_ca_topic_score_gemma":0.000001452169,"domain_scores_codex":[0.9989932,0.000005834483,0.0002391963,0.0002377624,0.0002752444,0.0002487396],"domain_scores_gemma":[0.999286,0.00009352429,0.00004593928,0.0001786412,0.0002140332,0.0001818917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007332658,0.0001095275,0.002261394,0.002200064,0.00002431851,0.0000266857,0.0001102179,2.059072e-8,0.9913771,0.00006273561,0.0006892866,0.002405387],"study_design_scores_gemma":[0.001102014,0.0002715276,0.004025386,0.0001683328,0.0000944314,0.00009708001,0.0005630226,0.0003546015,0.9928442,0.000108786,0.0002628028,0.0001078097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943458,0.001624331,0.002349445,0.0004663456,0.00003905647,0.0002549371,0.00002711083,0.0000206777,0.0008722612],"genre_scores_gemma":[0.9985124,0.00001648354,0.0006975221,0.0001087708,0.0001987696,0.00001741179,0.0000505128,0.00001634981,0.0003818134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00416653,"threshold_uncertainty_score":0.4359767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125968073773312,"score_gpt":0.3308055836015704,"score_spread":0.3095459028638373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}