{"id":"W2078434918","doi":"10.1128/jvi.74.16.7349-7361.2000","title":"Identification of Domains of the Human Papillomavirus Type 11 E1 Helicase Involved in Oligomerization and Binding to the Viral Origin","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Biology; Helicase; Minichromosome maintenance; DNA replication; Amino acid; DNA; Origin recognition complex; Viral replication; Replication factor C; Control of chromosome duplication; SeqA protein domain; Molecular biology; Cell biology; Biochemistry; Eukaryotic DNA replication; Virus; Virology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105271,0.0002818303,0.0001439114,0.0001573198,0.0001339223,0.0001992414,0.0001139584,0.000298543,0.0005953673],"category_scores_gemma":[0.0001741716,0.0001426198,0.0002300158,0.0001405527,0.0001658938,0.000215047,0.0001864728,0.0003926956,0.0004222059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502173,"about_ca_system_score_gemma":0.000217996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003835954,"about_ca_topic_score_gemma":0.0003793368,"domain_scores_codex":[0.9999433,0.00001093446,0.00000723423,0.00001552518,0.00001176423,0.0000112389],"domain_scores_gemma":[0.999838,0.00004735257,0.00004235474,0.00001689464,0.00001549976,0.0000399503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000957728,0.00003544726,0.000660237,0.00003119508,0.000002736798,0.00005196287,0.00001684277,0.00007907359,0.9979019,0.00007000248,0.00001328898,0.001041558],"study_design_scores_gemma":[0.00002328219,0.0002685622,0.03887004,0.00001422165,0.00002603871,0.00137026,0.00004681322,0.001447299,0.9537902,0.000175075,0.003958467,0.000009745809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959701,0.0007069567,0.002625427,0.00003180719,0.000004197258,0.0000212,0.0002596301,0.0000179809,0.0003627329],"genre_scores_gemma":[0.9930406,0.0003967251,0.004321058,0.0000336523,0.000004186597,0.00002395744,0.001303085,0.00001016358,0.0008667009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005953673,"threshold_uncertainty_score":0.001991689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191506422237427,"score_gpt":0.3204583822883273,"score_spread":0.3013077400645847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}