{"id":"W2078444226","doi":"10.1016/j.exger.2013.03.004","title":"Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion","year":2013,"lang":"en","type":"review","venue":"Experimental Gerontology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Sirtuin; SIRT3; Mitochondrial biogenesis; Mitochondrion; Caloric theory; Biology; Biogenesis; Reactive oxygen species; Cell biology; Acetylation; Biochemistry; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002521121,0.0009630018,0.001648388,0.002546294,0.0006061479,0.001886208,0.001656673,0.002417065,0.002562177],"category_scores_gemma":[0.003327078,0.0003201038,0.0004700302,0.003725995,0.00301423,0.003436466,0.001729513,0.004107239,0.0009264497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001578538,"about_ca_system_score_gemma":0.002518482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002462555,"about_ca_topic_score_gemma":0.005156709,"domain_scores_codex":[0.9995505,0.00008937347,0.00006543544,0.00009788198,0.0001573972,0.00003941611],"domain_scores_gemma":[0.9979064,0.001345745,0.0001536868,0.00006908729,0.0003982408,0.0001268036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001639357,0.00005269174,0.0004414763,0.01876494,0.0001532878,0.000466691,0.0002629983,0.0004076087,0.001815417,0.02110976,0.06005448,0.8963066],"study_design_scores_gemma":[0.00001454379,0.00003710325,0.0009011853,0.006014509,0.0001533719,0.001153626,0.0002944275,0.00007833663,0.0004159132,0.01451459,0.9763817,0.0000405353],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005079641,0.9979964,0.0001004805,0.001272115,0.0002524883,8.213074e-7,0.000008591724,0.000002779576,0.0003154738],"genre_scores_gemma":[0.0005333193,0.9979541,0.0001701861,0.0006778891,0.0004694221,0.000002705024,0.00001312487,0.000001296598,0.0001778601],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002562177,"threshold_uncertainty_score":0.01333314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09796994534948049,"score_gpt":0.3474999023282,"score_spread":0.2495299569787195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}