{"id":"W2078462908","doi":"10.1038/ng.478","title":"Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Children's & Women's Health Centre of British Columbia; Montreal Heart Institute; Université de Montréal; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ototoxicity; Thiopurine methyltransferase; Cisplatin; Hearing loss; Biology; Oncology; Cohort; Single-nucleotide polymorphism; Candidate gene; Pharmacogenetics; Genetics; Genetic predisposition; Bioinformatics; Pharmacology; Internal medicine; Chemotherapy; Gene; Genotype; Medicine; Audiology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529375,0.0001984217,0.0002071088,0.00007951927,0.00004000875,0.00003136272,0.0001450768,0.0004352613,0.000004534582],"category_scores_gemma":[0.00002092024,0.0001938459,0.00002742071,0.0002034289,0.00003044369,0.000002722136,0.00003676803,0.0003551843,3.391096e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003845997,"about_ca_system_score_gemma":0.00004914409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001403912,"about_ca_topic_score_gemma":0.0004329695,"domain_scores_codex":[0.9989048,0.00004261794,0.0001927016,0.0003995686,0.0001433921,0.0003169401],"domain_scores_gemma":[0.9995418,0.000008197378,0.00009510127,0.0002477434,0.00004359641,0.00006360279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001739375,0.0001689068,0.8568695,0.000007551488,0.00007350394,0.00002081866,0.0001622095,0.0005527136,0.1176732,0.00002524512,0.00004419982,0.02422817],"study_design_scores_gemma":[0.00191728,0.0003166149,0.9749818,0.00008103796,0.0000121339,0.00003303309,0.00001493952,0.0002669482,0.02156204,0.0003362453,0.0002200523,0.0002578378],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949461,0.004218902,0.0002073317,0.000193708,0.00005536127,0.0002638832,0.00001287249,0.000009052435,0.00009278105],"genre_scores_gemma":[0.9954662,0.001554155,0.00146206,0.001303693,0.0001007712,0.000006016163,0.00003037891,0.00002976268,0.00004693475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1181123,"threshold_uncertainty_score":0.7904807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476407377881841,"score_gpt":0.236822571477851,"score_spread":0.2313461640999692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}