{"id":"W2078462908","doi":"10.1038/ng.478","title":"Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Children's & Women's Health Centre of British Columbia; Montreal Heart Institute; Université de Montréal; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ototoxicity; Thiopurine methyltransferase; Cisplatin; Hearing loss; Biology; Oncology; Cohort; Single-nucleotide polymorphism; Candidate gene; Pharmacogenetics; Genetics; Genetic predisposition; Bioinformatics; Pharmacology; Internal medicine; Chemotherapy; Gene; Genotype; Medicine; Audiology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000333071,0.001115404,0.000647889,0.002211184,0.000734617,0.0007237059,0.0008937079,0.001097974,0.002982853],"category_scores_gemma":[0.004375352,0.0005616851,0.0007720852,0.002178628,0.001082795,0.0005113163,0.0006349776,0.001190416,0.0003226594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004699834,"about_ca_system_score_gemma":0.000610895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00651706,"about_ca_topic_score_gemma":0.003052598,"domain_scores_codex":[0.9991345,0.0001246846,0.0001223084,0.0001801198,0.0002766357,0.0001617199],"domain_scores_gemma":[0.9968285,0.001194636,0.001292803,0.00008035186,0.000193021,0.0004107564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001268736,0.0002059596,0.9409991,0.00007184952,0.0001949196,0.03872181,0.0005441305,0.000285579,0.01271688,0.0001551106,0.0004060106,0.00443],"study_design_scores_gemma":[0.00006106721,0.0004954153,0.9140841,0.00004287519,0.0003252118,0.08026971,0.000577474,0.0006750099,0.002801682,0.0001488728,0.0004897438,0.00002884044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998845,0.0002065165,0.0001565377,0.0001461982,0.00001472922,0.000007527673,0.0001365831,0.00001349539,0.0004733072],"genre_scores_gemma":[0.9994537,0.0001341904,0.0001330093,0.00003424323,0.00002059892,0.000005026371,0.00006862772,0.0000081956,0.0001424031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00651706,"threshold_uncertainty_score":0.01295823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476407377881841,"score_gpt":0.236822571477851,"score_spread":0.2313461640999692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}