{"id":"W2078464167","doi":"10.2174/156720111795256200","title":"Amino Acid-Substituted Gemini Surfactant-Based Nanoparticles as Safe and Versatile Gene Delivery Agents","year":2011,"lang":"en","type":"article","venue":"Current Drug Delivery","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Gene delivery; Lysine; Transfection; Amino acid; Biocompatibility; Glycine; Cytotoxicity; Biomolecule; Combinatorial chemistry; Toxicity; Peptide; Pulmonary surfactant; Nanoparticle; Biochemistry; Gene; In vitro; Organic chemistry; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001749648,0.0003606228,0.0002643868,0.0001028431,0.0001678464,0.00004876882,0.0003557899,0.0001501948,0.0002368362],"category_scores_gemma":[0.00004762369,0.0003591642,0.0001539483,0.0001203536,0.0002147811,0.00002985582,0.000227658,0.0001552269,0.0002571339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003467744,"about_ca_system_score_gemma":0.0001878104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142692,"about_ca_topic_score_gemma":0.00006858072,"domain_scores_codex":[0.99808,0.00009381493,0.0003770082,0.0006777105,0.0002392866,0.0005321577],"domain_scores_gemma":[0.9988551,0.00002017311,0.0001446763,0.0005180335,0.0001940719,0.0002680052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005267818,0.0003218466,0.01445809,0.0000562907,0.000132798,0.00004401312,0.0003942137,0.00002196437,0.9555237,0.0000172257,0.006079378,0.0224237],"study_design_scores_gemma":[0.001099342,0.0002121998,0.009948545,0.00007148199,0.00009871044,0.00001550879,0.000228505,0.0003477261,0.9789407,0.00003614135,0.008484717,0.0005163931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918076,0.006307405,0.00008134804,0.00002388876,0.0007671285,0.0002410653,0.00009639572,0.00004111202,0.0006340282],"genre_scores_gemma":[0.9965307,0.00212969,0.0004013213,0.0002809461,0.0001473293,0.00002896359,0.0002839675,0.00003404595,0.0001630777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02341702,"threshold_uncertainty_score":0.999886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03467620887604276,"score_gpt":0.2548742542012741,"score_spread":0.2201980453252313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}