{"id":"W2078464167","doi":"10.2174/156720111795256200","title":"Amino Acid-Substituted Gemini Surfactant-Based Nanoparticles as Safe and Versatile Gene Delivery Agents","year":2011,"lang":"en","type":"article","venue":"Current Drug Delivery","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Gene delivery; Lysine; Transfection; Amino acid; Biocompatibility; Glycine; Cytotoxicity; Biomolecule; Combinatorial chemistry; Toxicity; Peptide; Pulmonary surfactant; Nanoparticle; Biochemistry; Gene; In vitro; Organic chemistry; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616677,0.0003750898,0.0002606912,0.0002247624,0.0001086933,0.0002641059,0.0002465714,0.0004121824,0.0001480405],"category_scores_gemma":[0.0002131955,0.0001396121,0.000188254,0.0001928048,0.0002169024,0.0003925377,0.0002030505,0.0003316942,0.0001643481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696152,"about_ca_system_score_gemma":0.000211632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004924519,"about_ca_topic_score_gemma":0.001005036,"domain_scores_codex":[0.9998339,0.00004569887,0.00001874387,0.00002783209,0.00005737501,0.0000164642],"domain_scores_gemma":[0.9998882,0.00001725645,0.00004017981,0.000008419303,0.00002805714,0.0000179759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004406502,0.000009357652,0.00007608207,0.00004774121,0.000005270526,0.00004079318,0.00001661526,0.0002435532,0.9965604,0.0001761359,0.00002611964,0.002753888],"study_design_scores_gemma":[0.000006969206,0.0001607085,0.0002527789,0.00000362642,0.00001312704,0.00009957563,0.000008176932,0.001507391,0.9948415,0.00004295789,0.003058635,0.000004473638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486023,0.02091963,0.02803916,0.000216216,0.00007786634,0.00009294829,0.0001033855,0.0002204658,0.001727961],"genre_scores_gemma":[0.9626367,0.008587691,0.02571624,0.00009592201,0.00002494227,0.00004661136,0.0001528631,0.00004357354,0.002695494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004924519,"threshold_uncertainty_score":0.002681732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03467620887604276,"score_gpt":0.2548742542012741,"score_spread":0.2201980453252313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}