{"id":"W2078486154","doi":"10.1091/mbc.e05-12-1146","title":"Adenovirus E4orf4 Hijacks Rho GTPase-dependent Actin Dynamics to Kill Cells: A Role for Endosome-associated Actin Assembly","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Johns Hopkins University","keywords":"Biology; Cell biology; RHOA; GTPase; CDC42; Actin cytoskeleton; Cytoskeleton; Actin; Endosome; MDia1; Actin remodeling; Formins; Lamellipodium; Cell; Signal transduction; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734589,0.0003375619,0.0001229224,0.0001554501,0.0001408181,0.0002317556,0.0001613181,0.0002712826,0.0008886601],"category_scores_gemma":[0.00008622762,0.0001060259,0.0001909116,0.0000535867,0.0002013235,0.000190387,0.0001912427,0.0003281307,0.0002150626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003298205,"about_ca_system_score_gemma":0.0001625869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000257256,"about_ca_topic_score_gemma":0.0003069525,"domain_scores_codex":[0.9999157,0.00001768939,0.000005836202,0.00001391351,0.00002032479,0.00002646563],"domain_scores_gemma":[0.9999573,0.000007117536,0.000009963497,0.000008628488,0.000004647428,0.00001231639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004834329,0.00001386142,0.0001272026,0.000009285771,0.00000278718,0.0000316052,0.000003173856,0.00004385023,0.9987232,0.0002662743,0.00001512303,0.0007153508],"study_design_scores_gemma":[0.00001162895,0.0001098416,0.002525287,0.000002474399,0.000007904722,0.0002552436,0.00001078908,0.001250347,0.9940482,0.0000760414,0.00169978,0.000002326683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932265,0.0009941451,0.004163664,0.0001045357,0.00001911792,0.00001254173,0.00006274387,0.00007403555,0.001342957],"genre_scores_gemma":[0.9955172,0.0004692692,0.00157408,0.00002524032,0.000005115832,0.00001400937,0.0001210052,0.00001284501,0.00226136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008886601,"threshold_uncertainty_score":0.002972841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006885811613510872,"score_gpt":0.2650495623794445,"score_spread":0.2581637507659337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}