{"id":"W2078516985","doi":"10.1016/j.bmc.2012.05.004","title":"Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Antimycobacterial; Mycobacterium tuberculosis; Isoniazid; Mycobacterium bovis; Chemistry; Mycobacterium; Microbiology; Rifampicin; Tuberculosis; Antibiotics; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690409,0.000278784,0.0003359282,0.0001919431,0.0001203827,0.0002929016,0.0004767614,0.0004241182,0.002225675],"category_scores_gemma":[0.0001973688,0.0002017813,0.0002094177,0.0001383653,0.000143403,0.0002236103,0.0002366736,0.0005089066,0.0004421445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668814,"about_ca_system_score_gemma":0.0001536529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004656927,"about_ca_topic_score_gemma":0.001292212,"domain_scores_codex":[0.9998981,0.00002071869,0.00000677933,0.00001737703,0.00002313154,0.00003393262],"domain_scores_gemma":[0.9999324,0.00001351618,0.00001695024,0.000006981394,0.00001060751,0.00001956133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000625502,0.0001953391,0.0006135271,0.0002175507,0.00002631165,0.0004572336,0.0001000318,0.001168445,0.953399,0.001386818,0.0005354684,0.04127467],"study_design_scores_gemma":[0.0003602642,0.003669696,0.003566123,0.00005062074,0.00009445662,0.001499646,0.00004584849,0.00296458,0.9513812,0.0002653157,0.03607401,0.00002809398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590139,0.01898616,0.00965721,0.0004437917,0.0001585776,0.0001861025,0.0005405445,0.0001478743,0.01086584],"genre_scores_gemma":[0.9842481,0.005360365,0.005306167,0.0002318025,0.00004177133,0.00005577535,0.0005738344,0.00001281748,0.004169377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002225675,"threshold_uncertainty_score":0.007445574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915639287980139,"score_gpt":0.3027913876412567,"score_spread":0.2736349947614553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}