{"id":"W2078577337","doi":"10.1097/01.tp.0000330946.72185.ab","title":"RAPAMYCIN DECREASES CHOLESTEROL EFFLUX AND ABCA1 PROTEIN EXPRESSION WITHIN THP-1 MACROPHAGES","year":2008,"lang":"en","type":"article","venue":"Transplantation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"THP1 cell line; Efflux; ABCA1; Macrophage; Protein expression; Medicine; Traditional medicine; Pharmacology; Biology; Biochemistry; Cell culture; Transporter; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728252,0.00032989,0.0007738401,0.0003690902,0.0004087431,0.0006439632,0.0002240465,0.000481308,0.002495792],"category_scores_gemma":[0.0002293099,0.0002881852,0.0002961214,0.0003193805,0.0005718659,0.0003313661,0.000214379,0.001106804,0.001199161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004837893,"about_ca_system_score_gemma":0.0004215617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001754444,"about_ca_topic_score_gemma":0.002582664,"domain_scores_codex":[0.9994193,0.0001220816,0.00005190776,0.00007361949,0.0001345128,0.0001985218],"domain_scores_gemma":[0.9997184,0.00007133988,0.00005262621,0.00004761597,0.00004733376,0.00006266651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001129813,0.00006530985,0.0002816908,0.00005293106,0.00001187164,0.00008414053,0.00004386842,0.00004968199,0.9966623,0.00006619949,0.000325435,0.001226916],"study_design_scores_gemma":[0.0001380419,0.000991613,0.02154673,0.00001541194,0.00005708424,0.0005166324,0.0003252203,0.0008654416,0.9727616,0.00009570977,0.00266777,0.00001882255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941386,0.002386271,0.0005011365,0.0004852558,0.00008699447,0.00001196534,0.0006335221,0.00009398867,0.001662375],"genre_scores_gemma":[0.9933501,0.001454573,0.001003569,0.0002035537,0.00006909086,0.00003622829,0.0007212305,0.00003894246,0.003122729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002495792,"threshold_uncertainty_score":0.00834924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668667766449152,"score_gpt":0.2415649186051121,"score_spread":0.2248782409406206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}