{"id":"W2078587170","doi":"10.1021/bi3000287","title":"Heterotropic Cooperativity within and between Protomers of an Oligomeric M<sub>2</sub>Muscarinic Receptor","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Cooperativity; Muscarinic acetylcholine receptor; Cooperative binding; Chemistry; Receptor; Biochemistry; Binding site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000408049,0.0002968858,0.000464065,0.0001477193,0.000219011,0.0004271442,0.0005359225,0.0002934853,0.001012424],"category_scores_gemma":[0.0004616114,0.000280915,0.0003415686,0.00008012009,0.0005705911,0.0003251859,0.000330398,0.0003280125,0.0006177483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005403192,"about_ca_system_score_gemma":0.0001843209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005034548,"about_ca_topic_score_gemma":0.001162375,"domain_scores_codex":[0.9995419,0.00009428796,0.00003311559,0.0001505785,0.0001180371,0.00006213153],"domain_scores_gemma":[0.9995542,0.0001487666,0.0001148319,0.00008499835,0.00004635396,0.00005079187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006762,0.00002406895,0.0006772105,0.00003363843,0.00001260254,0.00005002947,0.00003313874,0.0001267831,0.9978076,0.0001938409,0.00003102755,0.0009094857],"study_design_scores_gemma":[0.00005268685,0.0003910648,0.03638314,0.00001125546,0.00007180309,0.001082355,0.00008994281,0.01266366,0.9459797,0.0004300136,0.002819429,0.00002502421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918911,0.000845889,0.005426768,0.00006644637,0.00001950718,0.00003756985,0.00005559453,0.00009909237,0.001557921],"genre_scores_gemma":[0.9968244,0.0002358944,0.001970776,0.00005249754,0.000008355999,0.00002759025,0.0001074834,0.00001522052,0.0007578732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012424,"threshold_uncertainty_score":0.003920257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143386107138185,"score_gpt":0.2438141074515809,"score_spread":0.2323802463801991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}