{"id":"W2078599058","doi":"10.1038/srep00480","title":"Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors","year":2012,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Alzheimer Society","keywords":"Hyperphosphorylation; GSK-3; Kinase; Phosphorylation; Cyclin-dependent kinase 5; Hypothermia; Genetically modified mouse; Cell biology; In vivo; Tau protein; Biology; Chemistry; Neuroscience; Pharmacology; Alzheimer's disease; Protein kinase A; Medicine; Transgene; Biochemistry; Internal medicine; Cyclin-dependent kinase 2; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003563803,0.000746237,0.0009288848,0.0005928332,0.0003093477,0.0005221387,0.0005637411,0.0005885617,0.001177516],"category_scores_gemma":[0.0001788459,0.0002526209,0.0006716906,0.0003428436,0.0005287794,0.0008902734,0.0005206158,0.002111485,0.0004545271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005409206,"about_ca_system_score_gemma":0.0003182094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004170135,"about_ca_topic_score_gemma":0.0005420496,"domain_scores_codex":[0.9997858,0.00005870328,0.00001647394,0.00004499765,0.00004389144,0.00005014912],"domain_scores_gemma":[0.9999067,0.00001562034,0.00002019679,0.00002085297,0.00001083447,0.00002591091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000669958,0.000310401,0.0003627614,0.0003529468,0.00004995744,0.0002460805,0.00005074048,0.00033701,0.9842963,0.002988979,0.0008093453,0.00952547],"study_design_scores_gemma":[0.0003803647,0.007588888,0.007084761,0.0001709142,0.0002398127,0.002982209,0.0001006314,0.004250141,0.9205854,0.003702019,0.05285088,0.00006400041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7092682,0.142539,0.1150988,0.004360349,0.002640216,0.001115232,0.002622478,0.001140978,0.0212148],"genre_scores_gemma":[0.8801078,0.06892288,0.03755228,0.0009632595,0.0006085253,0.001157914,0.001740939,0.0001299556,0.008816466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177516,"threshold_uncertainty_score":0.003939211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06391016572978354,"score_gpt":0.3355775505851977,"score_spread":0.2716673848554142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}