{"id":"W2078617491","doi":"10.1016/s1568-1637(03)00012-6","title":"Targeting DNA methylation in cancer","year":2003,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Biology; Methyltransferase; Cancer epigenetics; Carcinogenesis; Methylation; Epigenetics of physical exercise; RNA-Directed DNA Methylation; Epigenomics; Chromatin; DNA repair; DNA methyltransferase; Cancer research; DNA; Cancer; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007167537,0.0003394983,0.001094611,0.0003300408,0.000130942,0.00006791159,0.0003755797,0.0004603323,0.0000708952],"category_scores_gemma":[0.001678823,0.0002785421,0.0003422818,0.0008099103,0.00006487079,0.000005287167,0.0001792054,0.000699612,0.00009222829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001428498,"about_ca_system_score_gemma":0.0003576927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008170607,"about_ca_topic_score_gemma":0.00007623788,"domain_scores_codex":[0.9944531,0.002870511,0.0009759078,0.0007380002,0.0003656204,0.0005968679],"domain_scores_gemma":[0.9986899,0.0001301575,0.0003246927,0.0005920588,0.0001514721,0.0001117363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001414698,0.00002360138,0.00001352676,0.005345043,0.00002198454,0.000008037001,0.00001188988,0.000006309402,0.001458487,0.00001992394,0.001093653,0.9919961],"study_design_scores_gemma":[0.000078073,0.00005214036,0.000006345787,0.005055979,0.00004143226,7.185963e-7,0.000003374631,0.000004355186,0.0002102975,0.00006137999,0.9942133,0.0002725747],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005805786,0.9963765,0.0001620431,0.000009812234,0.0001778827,0.001624013,0.000009131701,0.000005179143,0.001577355],"genre_scores_gemma":[0.00001788219,0.9967052,0.0004645429,0.00001562169,0.0003989009,0.0007402578,0.0003251394,0.00007204081,0.001260444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931197,"threshold_uncertainty_score":0.9999667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2382802906123918,"score_gpt":0.4988973498918984,"score_spread":0.2606170592795066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}