{"id":"W2078627263","doi":"10.1074/jbc.c600270200","title":"Direct Assessment of CXCR4 Mutant Conformations Reveals Complex Link between Receptor Structure and Gαi Activation","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Receptor; Mutant; Chemistry; Ligand (biochemistry); Biophysics; Chemokine receptor; Protein structure; Biochemistry; Stereochemistry; Cell biology; Biology; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486211,0.0002855748,0.0002046425,0.0001100532,0.00008441575,0.0001740946,0.0001882648,0.0002550261,0.0009570933],"category_scores_gemma":[0.0001708609,0.0000915584,0.0002009766,0.000133356,0.0001952392,0.0001433726,0.0001345806,0.000437672,0.0001795593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308175,"about_ca_system_score_gemma":0.0001041587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005950329,"about_ca_topic_score_gemma":0.0005787412,"domain_scores_codex":[0.9998627,0.0000225466,0.000009663456,0.00003181715,0.00003096195,0.00004234395],"domain_scores_gemma":[0.9999051,0.00002264077,0.00003530761,0.000009679361,0.00000894087,0.00001830017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000168324,0.00001562598,0.000560264,0.00001325836,0.000005614246,0.00002682001,0.000009489166,0.0001265708,0.9983736,0.00005294303,0.00001735373,0.0006301525],"study_design_scores_gemma":[0.00002056103,0.0004318615,0.02052122,0.000005425876,0.00001819752,0.0003565867,0.00004777005,0.003120371,0.9749675,0.00007558129,0.0004258442,0.000008967504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983453,0.0002216018,0.0008567084,0.00003079929,0.000002939562,0.000006124611,0.0002202806,0.00001757866,0.0002986898],"genre_scores_gemma":[0.9982719,0.0001773279,0.0009137731,0.00003310649,0.000001294021,0.00001133706,0.000274168,0.00001010647,0.0003069248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009570933,"threshold_uncertainty_score":0.003201842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162430219877444,"score_gpt":0.2779328460923807,"score_spread":0.2563085438936062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}