{"id":"W2078627263","doi":"10.1074/jbc.c600270200","title":"Direct Assessment of CXCR4 Mutant Conformations Reveals Complex Link between Receptor Structure and Gαi Activation","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Receptor; Mutant; Chemistry; Ligand (biochemistry); Biophysics; Chemokine receptor; Protein structure; Biochemistry; Stereochemistry; Cell biology; Biology; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002492518,0.0001240423,0.000286186,0.00001922172,0.0000543234,0.00001825092,0.000123542,0.0002466281,0.0002063481],"category_scores_gemma":[0.00008514632,0.00008755703,0.0001012195,0.00005410092,0.00007005238,0.000007442419,0.00004680938,0.0001555899,1.476788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000196642,"about_ca_system_score_gemma":0.00004979657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002894863,"about_ca_topic_score_gemma":1.327118e-7,"domain_scores_codex":[0.9990479,0.0000423145,0.0005186832,0.0001275178,0.0001374919,0.0001261149],"domain_scores_gemma":[0.9990621,0.00004222366,0.0005458103,0.0001007983,0.0001835262,0.0000655861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002409854,0.00001669333,0.00493157,0.00002876553,0.00004182359,4.823872e-7,0.000006045977,0.00004094648,0.9938556,0.00002457424,0.0001982937,0.0008310908],"study_design_scores_gemma":[0.0003432154,0.0002093448,0.01396456,0.0000354745,0.00001679796,0.00001719566,0.00003526103,0.00001909784,0.9810057,0.0002919024,0.003955135,0.0001063576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969245,0.0001184058,0.002055959,0.0001387428,0.00003837965,0.00006075513,0.00008047184,0.000003573691,0.0005791961],"genre_scores_gemma":[0.9951386,0.00008955216,0.00376872,0.0000305017,0.0007024211,0.000001037297,0.0002247914,0.000006016688,0.00003831814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01284996,"threshold_uncertainty_score":0.3570472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162430219877444,"score_gpt":0.2779328460923807,"score_spread":0.2563085438936062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}