{"id":"W2078654278","doi":"10.1371/journal.pcbi.1002149","title":"Efficacy of Synaptic Inhibition Depends on Multiple, Dynamically Interacting Mechanisms Implicated in Chloride Homeostasis","year":2011,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Disinhibition; Biophysics; Homeostasis; GABAA receptor; Chemistry; Intracellular; Extracellular; Negative feedback; Chloride; Cell biology; Receptor; Neuroscience; Biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002945115,0.0004722542,0.0005547516,0.0002767087,0.0002985029,0.001061609,0.000466145,0.000467525,0.0005484818],"category_scores_gemma":[0.0006860335,0.000350185,0.0005838288,0.0001591466,0.0005160813,0.0009286281,0.0007679331,0.0005360303,0.0001604984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008220444,"about_ca_system_score_gemma":0.0005709025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328053,"about_ca_topic_score_gemma":0.0009030126,"domain_scores_codex":[0.9998366,0.00001912006,0.00001737137,0.00003731842,0.00005418485,0.00003533082],"domain_scores_gemma":[0.9997539,0.00008139839,0.00006557507,0.00002544462,0.00003736355,0.00003625166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002271861,0.0000874846,0.008987354,0.000162975,0.0001083225,0.000381398,0.0000913454,0.1183542,0.8525339,0.009094834,0.000172027,0.009798951],"study_design_scores_gemma":[0.00003943488,0.0001498767,0.01764319,0.00001591647,0.00008131638,0.0002358665,0.00006040385,0.8800436,0.09704898,0.003898774,0.0007226585,0.00006004959],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700361,0.0005073626,0.02607066,0.0001670045,0.00001760747,0.00001991304,0.00006391911,0.0002044589,0.002913035],"genre_scores_gemma":[0.9979424,0.0002821631,0.001448053,0.00001452474,0.000002651424,0.00001377839,0.00002316225,0.00001650366,0.0002568326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328053,"threshold_uncertainty_score":0.005964339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09391769126639186,"score_gpt":0.3366696119098376,"score_spread":0.2427519206434458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}