{"id":"W2078660820","doi":"10.4161/cc.11.5.19447","title":"Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin","year":2012,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"Oxaliplatin; Cisplatin; Cytotoxicity; Biology; Apoptosis; Cell cycle; Cell culture; Intracellular; DNA damage; Cell; Cytotoxic T cell; Biochemistry; Cancer research; DNA; Molecular biology; In vitro; Cancer; Chemotherapy; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003913096,0.0004121654,0.0007546826,0.0002551424,0.0001492187,0.00006267739,0.0001260613,0.0001451803,0.0002761839],"category_scores_gemma":[0.0001179515,0.0003544704,0.00005568593,0.0003264118,0.00008004349,0.000143914,0.000132153,0.000308507,0.00005005411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009233657,"about_ca_system_score_gemma":0.00005116269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003132751,"about_ca_topic_score_gemma":0.0002845717,"domain_scores_codex":[0.9974399,0.00009745076,0.0006493946,0.0005472562,0.0004175018,0.0008485345],"domain_scores_gemma":[0.9983774,0.0002668033,0.0001418534,0.0003755751,0.00005926084,0.0007791391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001980627,0.000315259,0.01791871,0.0003286008,0.00004451248,0.00001209053,0.02863242,0.00003648945,0.94371,0.00008475367,0.0001494199,0.006787114],"study_design_scores_gemma":[0.003434187,0.0006016286,0.8048583,0.0004602696,0.0001188234,0.0000150644,0.002403843,0.00181134,0.1822352,0.0001219694,0.003293359,0.000645981],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920365,0.0002935291,0.0002899568,0.0001407536,0.0001347495,0.001202428,0.0001982476,0.00004711171,0.005656695],"genre_scores_gemma":[0.9896519,0.00002381519,0.008782359,0.0004403032,0.00007982633,0.00005275794,0.00003808694,0.00005648718,0.0008745266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7869396,"threshold_uncertainty_score":0.9998907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05118597529638445,"score_gpt":0.2710040966367119,"score_spread":0.2198181213403275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}